Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report on dynamic changes in plasma corticosteroid-binding globulin (CBG) binding and basal hypothalamic-pituitary-adrenal (HPA) activity following acute stress in adult rats. Plasma CBG binding was significantly reduced at 24 and 48 h following a single 60 min period of restraint. Basal levels of plasma ACTH and total corticosterone (B) during the light phase of the cycle were elevated at 24 h following restraint. These effects occurred only when animals were stressed in the light phase of the cycle; animals exposed to restraint stress during the dark phase of the cycle showed no change in plasma CBG binding or in basal HPA activity. Pituitary intracellular transcortin, which is derived from circulating CBG, was also decreased by restraint stress. The decrease in CBG binding was also associated with a significant increase in resting-state free B levels. Together, these effects produced a substantially (i.e. approximately 10-fold) increased 'basal' glucocorticoid signal 24 h following acute stress. These data suggest that the increase in the circulating glucocorticoid signal associated with acute stress endures well beyond the period of increased total B levels.
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PMID:Dynamic variations in plasma corticosteroid-binding globulin and basal HPA activity following acute stress in adult rats. 908 66

Within studies of acute stress physiology an increase in glucocorticoid secretion is thought to be the primary mediator of tissue response to stress. Corticosteroid-binding globulin may regulate tissue availability of steroids, but has not been considered a dynamic component of the acute stress response. Here, we examined CBG level over the common 60-minute time frame in an acute capture and handling protocol to investigate whether CBG capacity is dynamic or static over short stressors. Using a comparative approach, we measured CBG response to capture and handling stress in nine species of birds, representing five orders and nine families. CBG capacity significantly declined within 30 - 60 minutes of capture in five of the nine species examined. This decline may serve to significantly increase the level of corticosterone reaching tissues during acute stress.
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PMID:Plasma-binding globulins and acute stress response. 1670 8