Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0848237 (
acute stress
)
4,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-18
(
IL-18
) has recently been considered a promising marker of stress responses. In this study, to evaluate
IL-18
as a noninvasive stress marker in pigs, we investigated the expression of
IL-18
in porcine salivary glands and its presence in saliva, and its dynamics during acute immobilization stress in pigs.
IL-18
mRNA was detected robustly in the pig salivary glands by RT-PCR. Immunohistochemical staining of
IL-18
protein expression revealed that the expression patterns differed among the three types of salivary glands (parotid, submandibular, and sublingual gland).
IL-18
was also detected in pig saliva by ELISA, and a diurnal rhythm with a peak in the afternoon was observed. The
IL-18
concentration in saliva was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of
IL-18
in pig saliva. Salivary
IL-18
may thus become a useful noninvasive marker for the evaluation of
acute stress
in pigs.
...
PMID:Interleukin-18 expression in pig salivary glands and salivary content changes during acute immobilization stress. 2168 50
