Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0848237 (
acute stress
)
4,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related to certain mental disorders. However, whether stress as an environmental factor leads to changes in polySia structure is unknown. Here we studied the effects of
acute stress
on polySia expression and found reductions in both the quantity and quality of polySia in the olfactory bulb and prefrontal cortex, even with short-term exposure to
acute stress
. The use of inhibitors for
sialidase
, microglia and astrocytes revealed that these declines were due to a transient action of
sialidase
from microglia and astrocytes in the olfactory bulb and prefrontal cortex, respectively. These data suggest that
sialidase
dynamically regulates polySia expression in a brain region-specific manner.
...
PMID:Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain. 3128 15
