Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of neonatal administration ofverapamil, a calcium L-type channel blocker, on the stress and noradrenergic responses of hypothalamo-pituitary-adrenal (HPA) axis in adult female rats with anovulatory syndrome induced by neonatal androgenization have been studied. There was no adrenocortical response to an acute stress nor noradrenaline infusion in the 3rd brain ventricle in females with persistent estrus. Verapamil pretreatment completely restored the adrenocortical responses to normal level. No changes were found in studied parameters following treatment with verapamil alone. These results demonstrate possible involvement of calcium signalling in pathogenesis of the disorders of HPA function in adult female rats, induced by neonatal androgenization.
 ...
PMID:[Calcium-dependent mechanisms of stress disorders and noradrenergic responses of the hypothalamo-pituitary-adrenal system in neonatally androgenized female rats]. 1922 36

This study was designed to investigate an interaction between acute restraint stress and corticosterone with verapamil, a blocker of L-type voltage-dependent calcium (VDC) channels on retrieval of long-term memory. Young adult male rats were trained in one trial inhibitory avoidance task (0.5 mA, 3 s footshock). On retention test given 48 h after training, the latency to re-enter dark compartment of the apparatus was recorded. In Experiment 1, verapamil pretreatment (5, 10, or 20 mg/kg) enhanced the impairing effects of acute stress (which was applied for 10 min in a Plexiglass tube 30 min before the retention test) on memory retrieval. The applied stress increased circulating corticosterone levels as assessed immediately after the retention test, indicating that stress-induced impairment of memory retrieval is mediated, in part, by increased plasma levels of glucocorticoids. Verapamil did not change this response. In Experiment 2, pretreatment of an intermediate dose of verapamil also enhanced corticosterone-induced impairment of memory retrieval. In Experiments 3 and 4, acute stress or corticosterone did not change motor activity with or without prior treatment of verapamil, suggesting that stress or glucocorticoid-induced impairment of memory retrieval is not due to any gross disturbances in motor performance of animals. These findings indicate that blockade of L-type VDC channels enhances stress or glucocorticoid-induced impairment of memory retrieval, and provide evidence for the existence of an interaction between glucocorticoids and L-type VDC channels on memory retrieval.
 ...
PMID:Verapamil enhances acute stress or glucocorticoid-induced deficits in retrieval of long-term memory in rats. 1939 65