Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In various stressful conditions, the thymus is subjected to incidental involution, mostly due to the thymocytolytic effect of secreted glucocorticosteroids. The aim of this study was to examine acute thymic involution in sick neonates and to compare the morphological grade with some clinical and laboratory parameters. The influence of the illness on thymus tissue was investigated in 100 neonates who were treated and died in a neonatology intensive care unit. The preterm infants (n = 73) were born before the 37th week of gestation. Analysis of 57 placentas showed inflammation in 32% and circulatory disturbances in 23% of the cases. The causes of death were confirmed by autopsy: 35 were preterm infants with respiratory distress syndrome without infection, 22 were malformed, and 10 had birth trauma or asphyxia. In contrast, 29 of the preterm infants had an infection, mostly pneumonia or sepsis, and 4 of the term infants had such infections. Acute thymus involution was histologically graded (0-4) according to the method of van Baarlen (see text). Resting state (grade 0) was found in 25 of 38 neonates who lived <12 h. In 13 of 38 neonates who lived <12 h, thymus involution suggested prenatal stress. The grade of thymus involution related to the duration of illness (p < 0.001). Placental inflammation was associated with features of thymus involution (p < 0.048). Infection as a cause of death was connected to advanced thymus involution (p < 0.001). In preterm newborns, infection was more often connected with acute thymus involution than was respiratory distress syndrome (p < 0.003). Among the parameters measured in all available peripheral blood samples taken 24 h before death, only the lymphocyte count related to the grade of acute thymus involution (p < 0.05), with an increase in percentage of lymphocytes in peripheral blood smears from grade 0 to 2 and a decrease from grade 2 to 4. Although the white blood cell count is highly variable, a low percentage of lymphocytes might be a sign of advanced accidental thymus involution following acute stress.
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PMID:The grade of acute thymus involution in neonates correlates with the duration of acute illness and with the percentage of lymphocytes in peripheral blood smear. Pathological study. 1274 50

Human confrontation with such a stressor as the COVID-19 pandemic outbreak, caused by SARS-CoV-2 virus, manifested in severe acute respiratory distress, results also in the decrease of fitness and mental resistance on an unprecedented scale and with difficult to estimate consequences [1]. More important than the intensity of the disorder is its prevalence. When we compare our current knowledge of the impact of the pandemic on the development of mental disorders with the findings of research on acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) over the last 40 years, it may turn out that they are different from each other, the symptomatic spectrum of mental disorders varies and the possibilities of an effective treatment are very limited. We cannot rule out that a new diagnostic category for specific mental disorders resulting from the COVID-19 pandemic may emerge in the near future. This paper presents the extent of the impact of the pandemic on the development of mental instability and current diagnostic possibilities. Subpopulations necessary for planning short-term intervention in the organisational, informative and medical areas were identified. A psychiatric guide for immediate support and assistance was proposed.
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PMID:Impact of COVID-19 pandemic on mental health. 3277 53