Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0848237 (
acute stress
)
4,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Immune system function is affected by a variety of exogenous and endogenous stressors. Most studies have focused on the effect of stressors on immune function, but not necessarily on trade-offs within the immune system and interactions with energy-mobilizing hormones. In this study, we examined how bactericidal ability and corticosterone interacted by applying acute restraint stress in a non-model organism, the side-blotched lizard (
Uta
stansburiana), 10 days after receiving a cutaneous wound. We found a decrease in bactericidal ability in wounded animals after restraint stress. However, the percentage healed during the first 7 days was positively correlated with bactericidal ability 10 days after wounding. In addition, the magnitude of change in corticosterone concentration during the
acute stress
was positively correlated with the percentage of wound healing during the first 3 days. These two relationships may demonstrate a "faster is better" strategy. If energy is invested heavily in the initial wound healing stages, the individual may be able to mount a more effective immune and stress response earlier.
...
PMID:Wound healing reduces stress-induced immune changes: evidence for immune prioritization in the side-blotched lizard. 2473 88
Reptiles rely on thermal heat exchange to achieve body temperatures (T
body
) conducive to maintaining homeostasis. Diurnal changes in the thermal environment are therefore liable to influence allostatic mediation of survival processes (e.g., immunity) during environmental challenges or stressors. However, the extent to which T
body
prompts individual variation in physiology remains largely unexplored in reptiles. Our study tested how circulating energy-mobilizing hormone, energy metabolites, and immunity can vary across basal and stress-induced allostatic states for plateau side-blotched lizards (
Uta
stansburiana uniformis) residing in a heterogeneous thermal environment. We collected baseline and
acute stress
blood samples from male lizards to compare changes in plasma corticosterone (CORT), glucose, and bacterial killing ability (BKA) in relation to each other and T
body
. We hypothesized each physiological parameter differs between allostatic states, whereby stress-induced activity increases from baseline. At basal and stress-induced states, we also hypothesized circulating CORT, glucose, and BKA directly correspond with each other and T
body
. We found both CORT and BKA increased while glucose instead decreased from
acute stress
. At basal and stress-induced allostatic states, we found CORT to be directly related to T
body
while BKA was inversely related to CORT. We also found BKA and glucose were directly related at baseline, but inversely related following
acute stress
. Overall, these results demonstrate allostatic outcomes from
acute stress
in a free-living reptile and the role of temperature in mediating energetic state and immunity. Future research on reptilian allostasis should consider multiple environmental conditions and their implications for physiological performance and survival.
...
PMID:Glucocorticoids, energy metabolites, and immunity vary across allostatic states for plateau side-blotched lizards (Uta stansburiana uniformis) residing in a heterogeneous thermal environment. 3295 93
