Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Social grouping and isolation of mice, in the presence of an acute stressor, were found to differentially affect the antitumor action of the immunological adjuvant Corynebacterium parvum. Socially grouped DBA/2j mice were injected intradermally with P815 mastocytoma ascites cells. Half the mice had a threshold dose of C. parvum admixed with the P815 cells. Half the mice in each of those conditions were given acute, inescapable electric footshock. In a second experiment, the stressed mice were socially isolated prior to the acute stress. Tumor growth itself was not affected by the stress procedures. C. parvum inhibited tumor growth in non-stressed and socially isolated, stressed mice. However, social grouping selectively negated the C. parvum effect resulting in tumor growth and mortality equivalent to mice not given the adjuvant. Psychological factors may be important to the development of concomitant immunity and the efficacy of immunotherapies.
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PMID:Modification of the antitumor action of Corynebacterium parvum by stress. 309 54

Growth of P815 mastocytoma in syngeneic DBA/2J male mice was evaluated following several stress regimens. Although escapable shock did not enhance tumor growth, an equivalent amount of inescapable shock applied in a yoked paradigm markedly augmented tumor development. If mice received repeated stress sessions on 5-10 consecutive following tumor cell transplantation, the tumor-enhancing effects of an acute session were abrogated. This effect was not due to an antitumor effect exerted by a shock session applied several days after cell transplantation. It seems that the tumorigenic effects of stress are subject to adaptation since stress exposure prior to cell transplantation also inhibited the effects of an acute stress session. The data were discussed in relation to stress-induced neurochemical alterations.
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PMID:Adaptation to the tumor-enhancing effects of stress. 679 49