Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.
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PMID:Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice. 325 74

We present our observations on 2 cases of stress cardiomyopathy in which, for the first time, wall motion and myocardial deformation analysis were performed by 2D-strain imaging. Strikingly, in both patients, serial 2D-strain wall motion analysis revealed always synergic and synchronic longitudinal strain and strain-rate patterns, even during the acute stress-induced episodes of left ventricular (LV) dysfunction, indicating uniform myocardial shortening, despite akinetic appearance of the LV apex in both conventional echocardiography and ventriculography. Another important observation was that during the acute stress-induced episodes of severe LV dysfunction the end-systolic LV circumferential wall stress became in both patients several times higher in apical regions than at the LV base. These data suggest that the akinetic appearance of the apex can be related to the high systolic circumferential wall stress in this region, which opposes circumferential fiber shortening and thus apical akinesia and ballooning could be mainly the consequences of LV geometry-induced regional differences in wall stress, rather than a result of severely impaired myocardial contractility in apical regions.
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PMID:Left ventricular wall motion abnormality and myocardial dysfunction in stress cardiomyopathy: new pathophysiological aspects suggested by echocardiography. 2023 Oct 38

Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth decade of life. Etiology has not been clarified yet and several hypotheses have been postulated: multiple epicardial coronary artery damage, abnormal coronary microcirculation, catecholamine-mediated cardiac toxicity, and neurogenic stunning. Clinical presentation is not easy to distinguish from an acute coronary syndrome: chest pain at rest or dyspnea, new-onset electrocardiographic changes, characterized by ST-segment elevation or T-wave inversion. Coronary angiography, which should be performed within 48 h of symptom onset in order to be diagnostic, excludes the presence of significant atherosclerotic stenosis or plaque rupture. Ventricular angiography shows the typical regional wall motion abnormalities (apical akinesia and hyperkinesia of the mid-basal segments) that give to the syndrome its name (takotsubo is a traditional Japanese octopus trap or pot). Echocardiography performed in the acute phase also evidences wall motion abnormalities that characteristically regress in the following days. There is no specific treatment for this syndrome, but supportive and symptomatic therapy is usually administered.
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PMID:[Takotsubo cardiomyopathy: a consensus document]. 2010 3