Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848237 (acute stress)
 4,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In different tissues alteration of protein synthesis has been observed during acute stress. In this review we characterise the modulation of pancreatic protein synthesis during inflammation. A sustained decrease of mRNA levels of secretory enzymes is accompanied by noncoordinated alterations of protein synthesis during the acute phase and the recovery from pancreatitis. For that regulation both translational and transcriptional alterations are of importance. The most prominent finding was the expression of pancreatitis-associated proteins (PAP) in humans or rats, which are absent in the normal gland but synthesised during acute pancreatitis. PAPs are pancreatic secretory proteins, their mRNA were cloned and sequenced and the sequence of encoded preproteins of 175 amino acids were deduced. The PAP expression increased as a function of the severity of pancreatitis. It can be assayed in serum and may be used as a marker of the disease. Due to its affinity to bacterial surfaces the PAP molecule could act as an endogenous antibiotic factor that prevents the bacterial infection of the inflamed pancreas.
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PMID:The acute phase reaction of the exocrine pancreas. Gene expression and synthesis of pancreatitis-associated proteins. 818 76

We have previously shown that the acute phase reaction of the pancreas is a powerful emergency mechanism which protects the organism against further pancreatic aggression. In an attempt to understand the mechanisms involved in this protective effect we tried to characterize at the molecular level the phenotypic changes of the pancreatic cell during acute stress. Using a systematic approach, we identified the PC3/TIS21/BTG2 mRNA as strongly overexpressed in pancreas during the acute phase of pancreatitis. PC3/TIS21/BTG2 mRNA is also overexpressed in liver and kidney during acute pancreatitis but not in the other tissues analyzed. In addition, PC3/TIS21/BTG2 mRNA is overexpressed in kidney after a 30-min ischemia. Since acute pancreatitis and kidney ischemia-reperfusion-induced injury were associated with apoptosis, and PC3/TIS21/BTG2 has an antiapoptotic activity, we speculate that this protein may play a role in the control of apoptosis progression in these tissues.
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PMID:Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats. 971 37