Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute, subacute and chronic toxicity studies of 2-phosphonoxy benzoic acid (fofosal) were carried out in several animal species. LD50 values in mice and rats were determined at two pH values; an additional toxic effect of acidity was found at the lowest pH tested (pH = 1.0), specially so by i.p. route. Differences in LD5- values between mice and rats of either sex were not significant; however, acute toxicity of male rabbits was higher than that of rats and mice. Long-term toxicity studies revealed a slight growth retardation and a significant mortality at the highest dose tested (500 mg/kg). These studies showed that fosfosal produced no hematological, blood chemical or pathological changes.
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PMID:Acute, subacute and chronic toxicity of fosfosal. 696 16