Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0847097 (
acidity
)
15,165
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Furan-2-carbohydrazides were found as orally active
glucagon receptor
antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series of derivatives obtained by modifying the
acidity
of the phenol. We identified the ortho-nitrophenol as a good scaffold for
glucagon receptor
inhibitory activity. Our efforts have led to the discovery of compound 7l as a potent
glucagon receptor
antagonist with good bioavailability and satisfactory long half-life.
...
PMID:Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists. 2512 1
