Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Association of age with gastroesophageal pH and motor parameters have been searched for previously, but most studies have been cross-sectional. The aim of the present investigation was to evaluate the influence of age on gastroesophageal sphincter pressure, acid clearing ability, and acid gastroesophageal reflux in the same group of normal subjects. Ten healthy subjects were investigated in the period May 4, 1977, to February 18, 1978, and reinvestigated in the period August 19, 1985, to January 29, 1986. The median interval between the two investigations was 8.0 yr, range 7.7-8.5 yr. There were eight men and two women, with a median age at the second investigation of 36 yr, range 30-53 yr. Measurement of gastroesophageal sphincter pressure (GESP) and an acid perfusion test were performed, and within the same week, an acid-clearing test and a prolonged monitoring of pH in the distal part of the esophagus were carried out (5 cm proximally to the GES). pH monitoring was initiated between 7 and 8 PM and terminated between 7 and 8 AM. There were no changes in GESP between the two investigations. All had a normal acid perfusion test in both investigations. No changes in acid-clearing ability could be demonstrated. Similarly, the number of reflux episodes, as well as the duration of acid reflux, were unchanged. Integration of the pH curve for pH values less than or equal to 4 gave similar results at both occasions. In addition, the relative time with pH values less than or equal to 4 was unchanged. The acidity of the potential reflux material did not change over time, as evaluated by intragastric pH before and after monitoring. In conclusion, this study did not demonstrate any influence of age on esophageal acid defense mechanisms or spontaneous gastroesophageal reflux.
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PMID:The influence of age on esophageal acid defense mechanisms and spontaneous acid gastroesophageal reflux. 337 18

Our previous studies have demonstrated that the total triterpenes from the fruits of Chaenomeles speciosa (CSTT) exhibit effective therapeutic effects on gastric ulcer patients and animals. The present aim is to further investigate the mechanisms involved. The results indicated that CSTT could ameliorate IND-induced gastric injury, which was related to promoting IND-damaged GES-1 cell proliferation and migration, improving the IND-damaged rat GBF, ulcer area, inhibition rate and pathologic changes of gastric mucous tissue, increasing the amount of adhered gastric mucus, attenuating the volume and total acidity of the gastric effluents, and augmenting the gastric pH; further studies showed that CSTT obviously downregulated miR-423-5p mRNA, NAG-1 mRNA and protein expression, Bax, Bad, cytosol cytochrome C, Apaf-1, cleaved-caspase-3, and cleaved-caspase-9 protein expression and cytosol cytochrome C concentration, and upregulated TFF1, TFF2 and TFF3 mRNA and protein expression, Bcl-2, Bcl-xl, pro-caspase-3, and pro-caspase-9 protein expression, mitochondrial viability, mitochondrial cytochrome C concentration and Bcl-2/Bax, Bcl-xl/Bad ratios. These findings demonstrated that CSTT protected against IND-induced gastric damage by depressing miR-423-5p expression and modulating the TFF/NAG-1 pathway, which in turn restrained mitochondrion-mediated apoptosis.
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PMID:Total triterpenoids from the fruits of Chaenomeles speciosa exerted gastroprotective activities on indomethacin-induced gastric damage via modulating microRNA-423-5p-mediated TFF/NAG-1 and apoptotic pathways. 3189 80