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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The calculolytic effect of a diet designed to reduce the urine concentration of urea, P, and Mg was evaluated in female Beagles with induced urease-positive urinary tract infections and struvite urolithiasis and in female Beagles with induced sterile struvite urolithiasis. The reduced-protein calculolytic diet induced urolith dissolution in 5 of 6 infected dogs with struvite urolithiasis in 2 to 5 months (means = 14.4 weeks). At the end of 6 months, uroliths in comparable control dogs fed a maintenance diet were 5 times larger and 14 times heavier than at the beginning of the study. The calculolytic diet induced urolith dissolution in 6 of 6 noninfected dogs with struvite uroliths in 2 to 4 weeks (means = 3.3 weeks). Four uroliths in noninfected dogs fed the maintenance diet dissolved over a period of 2 to 5 months (means = 14 weeks). Urolith dissolution in dogs fed the calculolytic diet was associated with diet-induced diuresis, reduction in urine pH, reduction in urine concentration of urea ammonia, P, and Mg, and increase in urine titratable acidity. Consumption of the calculolytic diet was also associated with significant (P = less than 0.01) reduction in the serum concentration of urea and albumin and a significant (P = less than 0.01) increase in serum hepatic alkaline phosphatase activity. Concomitant occurrence of hydropic degeneration of hepatocytes indicated that these biochemical and morphologic changes were associated with dietary protein restriction.
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PMID:Evaluation of a calculolytic diet in female dogs with induced struvite urolithiasis. 647 63

It is known that Pi normally provides the major source of non-NH3 urinary buffer and that Pi-buffered renal H+ excretion (titratable acidity, TA) accounts for a large fraction of daily renal net acid excretion (NAE). Whether the presence of luminal non-NH3 buffers is a prerequisite to normal renal regulation of systemic acid-base equilibrium under any conditions has not been investigated. Accordingly, I investigated whether chronic renal regulation of plasma (p) [HCO3] might be impaired under conditions of normophosphatemic hypophosphaturia (NHP) produced by short-term dietary Pi restriction. During a steady-state of HCl-induced acidosis in NaCl-replete NHP dogs (group 1A, N = 6), [HCO3-]p averaged 14.1 +/- 0.6 mEq/liter and arterial (a) [H+] averaged 54 +/- 2 nEq/liter. Substitution K+ 2.5 mEq/kg as neutral Pi for equivalent dietary KCl for 7 to 8 days resulted in significant amelioration of acidosis (delta [HCO3-]p + 2.2 +/- 0.5 mEq/liter, P less than 0.01; delta [H+]a -6 +/- 2 nEq/liter, P less than 0.01) in association with a cumulative increment (sigma delta) in TA excretion (+ 103 mEq, P less than 0.001) and NAE (+ 22 mEq). To investigate whether Pi-induced amelioration of acidosis was related to enhanced urinary buffer capacity, an additional group (group 1B, N = 5) with NHP and chronic HCl acidosis was administered the non-Pi buffer, neutral creatinine (5.0 mmoles/kg daily). As with Pi, acidosis was ameliorated by creatinine administration and sigma delta NAE increased.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Hypophosphaturia impairs the renal defense against metabolic acidosis. 651 76

The effects were studied of sodium monensinate dosed 125 mg on the metabolic profile of rumen fluid. The experiment was conducted under current farming conditions in a pavilion cattle fattening house. The experiment, which lasted 367 days, comprised 985 bulls of the Bohemian Spotted breed. The feed ration was based on silage with an additive of dried poultry litter and concentrates. The additive was administered in concentrate mixture, 125 mg per head/day. After the start of the experiment want of appetite to sodium monensinate was observed. The animals took approximately four weeks to adapt completely to the additive. The following characteristics were investigated to study the metabolic profile of rumen fluid: actual acidity, total titration acidity, ammonia, total nitrogen, lactic acid, total volatile fatty acids, per cent acetic acid, per cent propionic acid, molar ratio acetic acid: propionic acid, per cent iso- and n-butyric acid, absolute number of infusoria and energy net yield of volatile fatty acids. Increased levels of the clinico-biochemical parameters of the metabolic profile of rumen fluid were found in lactic acid, propionic acid and energy net yield of volatile fatty acids. The per cent of propionic acid increased at some samplings by up to 116%. A drop was recorded in total nitrogen, per cent acetic acid, per cent butyric acid, molar ratio C2 : C3 and total number of infusoria. The decrease in the per cent of acetic acid ranged around 16% and the drop in butyric acid level amounted at some samplings up to 78%. No response to the additive was observed in the other characteristics of the metabolic profile of rumen fluid.
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PMID:[The effect of Rumensin on the metabolic profile of rumen fluid in feedlot cattle]. 677 40

The amino acid composition, the electrolyte content, the titratable acidity, the osmolality and the pH of nine crystalline amino acid mixtures and one protein hydrolysate was analyzed and the results were compared with the data provided by the manufacturer. The amino acid composition of the protein hydrolysate (Aminosol 10%) showed a marked discrepancy between the concentration of amino acids measured and the concentration given by the manufacturer. The sodium, chloride and especially the ammonia content is high as compared to the synthetic amino acid solutions. The amino acid composition of the crystalline amino acid solutions was generally in reasonable good agreement with the composition given by the manufacturers. In DL-Trophysan an unknown amino acid, probably alloisoleucine, was found. Only in two (Vamin 7% and Amino acid solution 4200) out of eleven crystalline amino acid mixtures cystine and tyrosine could be detected; therefore only Amino acid solution 4200 and Vamin 7% might be suited for infants. However, infants fed parenterally with Vamin 7% often showed elevated levels of several amino acids. Amino acid solution 4200 with a composition similar to human milk seems to be more adapted and needs further investigation.
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PMID:Amino acid solutions: composition and suitability for intravenous feeding in infants. 678 26

Different mechanisms responsible for acidosis following ureterocolic implantation into the continuity of the colon are reviewed. An acid urine is excreted by the kidneys in patients with acidosis, as in normal subjects. The acidity of the urine emitted into the colon stimulates bicarbonate secretion by the colic mucosa, and reabsorption of chloride. Acidosis following ureterocolic implantation could be related to bicarbonate loss in the stools, a renal acidosis mechanism not being involved as an acid urine is being excreted into the colon. An interesting point is that spontaneous regulation of this acidosis occurs, the bicarbonates secreted by the colon, as well as the ammonia, being secondarily reabsorbed during stagnation of the urine in contact with the colic mucosa. Oral administration of bicarbonates provokes alkalinization and suppression of loss of bicarbonates from the colon, with resulting correction of the acidosis.
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PMID:[Disorders of acid-base equilibrium in ureterocolic implantation]. 686 64

From each of 2 tetanic herds and 1 control herd 20 cows were randomly selected to determine serum levels of Mg, Ca, inorganic P, Na, K, Cl-, total protein, urea, GOT-activity and blood-glucose level. In rumen fluid the number of ciliates, ammonia, level, pH and total acidity were examined. Haematological investigations were carried out. Moreover dry matter and height of the herbage were measured, and meteorological measurements were utilized. The investigations were carried out before grazing and than on the 4th, 8th, 12th, and 16th day of grazing. Symptoms of metabolic disturbances and alcalic indigestion were found to be more distinct in the tetanic herds than in control herd. The method of MgO-pulverization on pastures was found to be useless. On the other hand, MgO-food-supplementation according to generally known methods was found to be of high usefulness. MgO-treatment at a dose of 50 g per cow and day in a period of 14 days before grazing effectively prevented the outbreak of hypomagnesaemia in spite of such tetanogenic factors as unfavourable weather, insufficience of dry matter in the herbage and subclinical alcalic indigestion with disturbed nitrogen metabolism.
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PMID:[Effect of preventive treatment of acute hypomagnesemia on the biochemical and morphological indicators in cows during the grazing period]. 716 97

Renal electrolyte excretion patterns were determined in nonedematous healthy volunteers following bumetanide and furosemide in two separate clinical studies. In study 1, intravenous bumetanide was administered to 24 subjects at four dose levels. In study 2, bumetanide (1 or 2 mg) or furosemide (40 or 80 mg) was administered in a single oral dose to 32 subjects assigned at random to one of the four treatment groups. In study 1, there was a significant dose-related increase in urine volume and sodium, potassium, and chloride excretion, with chloride exceeding sodium at all dose levels, and the Na+/K+ ratios after bumetanide were greater than 3:1. In study 2, the Na+/K+ ratio increased significantly after treatment in all four treatment groups. The relative Na+/K+ ratios showed higher natriuretic potency and lower kaliuretic potency for bumetanide than for furosemide, but the differences were not statistically significant. Additionally, all four treatment groups demonstrated elevation in titratable acidity, ammonia formation, and total acid excretion. There was a significant degree of positive correlation in the bumetanide-treated groups between Na+/K+ and the three variables. In the furosemide-treated groups, this positive correlation was statistically significant between the Na+/K+ ratio and ammonia and total acid secretion but not for titratable acidity. The results support the view that increased H+ formation after the administration of loop diuretics has a relative potassium-sparing effect.
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PMID:Renal electrolyte excretion pattern in response to bumetanide in healthy volunteers. 733 70

We describe a procedure for the determination of hydrochloric acid concentration in gastric juice by means of a conductometric titration of the 50-fold diluted sample with an aqueous ammonia solution. The conductometric method of endpoint indication leads to a definite location of the equivalence point in the titration of hydrochloric acid. The proposed method is simple and accurate and shows a good correlation with an accepted method for the measurement of gastric acidity.
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PMID:Conductometric titration of hydrochloric acid in gastric juice. 743 41

A large number of studies have indicated associations between particulate air pollution and adverse health outcomes. Wintertime air pollution in particular has been associated with increased mortality. Identification of causal constituents of inhalable particulate matter has been elusive, although one candidate has been the acidity of the aerosol. Here we report measurements of acidic aerosol species made for approximately 1.5 years in Erfurt, Germany, and Sokolov, Czech Republic. In both locations, the burning of high-sulfur coal is the primary source of ambient air pollution. Twenty-four-hour average measurements were made for PM10, [particulate matter with an aerodynamic diameter (da) < or = 10 microns], as well as fine particle (da < 2.5 microns) H+ and SO4(2-) for the entire study. Additionally, separate day and night measurements of fine particle H+, SO4(2-), NO3-, and NH4+ and the gases, SO2, HNO3, HONO, and NH3 were collected with an annular denuder/filter pack system over a 7-month (late winter-summer) period with additional measurements during pollution episodes the following winter. At both sites, 24-hr SO2 (mean concentrations of 52 micrograms/m3, with peak levels of > 585 micrograms/m3) and PM10 (mean concentration 60 micrograms m3) concentrations were quite high. However, aerosol SO4(2-) concentrations (mean concentration of approximately 10 micrograms/m3) were not as great as expected given the high SO2 concentrations, and acidity was very low (mean concentration of < 1 microgram/m3, with peak levels of only 7 micrograms/m3). Low acidity is likely to be the result of NH3 neutralization and slow conversion of SO2 to SO4(2-).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Measurement of acidic aerosol species in eastern Europe: implications for air pollution epidemiology. 765 78

The application of pH-zone-refining counter-current chromatography (CCC) to the preparative separation of stereoisomeric acids is described. The separation was accomplished on the basis of the difference in acidity of the two stereoisomers. pH-Zone-refining CCC of 400 mg of a crude synthetic mixture of stereoisomeric 1-methyl-4-methoxymethylcyclohexanecarboxylic acids yielded 49.5 and 40 mg of the pure Z- and E-stereoisomers respectively. The two-phase solvent system consisted of hexane-ethyl acetate-methanol-water (1:1:1:1). Trifluoro acetic and octanoic acids were used as retainer acids. The eluent base was aqueous ammonia. The eluted fraction were monitored by gas chromatography-mass spectrometry.
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PMID:Preparative separation of stereoisomeric 1-methyl-4-methoxymethylcyclohexanecarboxylic acids by pH-zone-refining counter-current chromatography. 784 45


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