Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of this study was to analyze the chemical and nutritional composition of two flours obtained from food subproducts (multimixtures): MM1 based on rice bran and MM2 based on wheat bran. This was done by identifying their macronutrients and performing analyses to determine characteristics such as rancidity, alcohol-soluble acidity, pH and presence of fungi (molds and yeasts) that could affect their quality. Our results show that MM1 has a greater content of nutrients such as lipids, insoluble fibers, calcium, and iron, while MM2 has a higher content of glycids and phosphorus. However, protein contents were similar in both samples. A high index of alcohol-soluble acidity was observed in MM1, and rancidity and high acidity were detected in both samples. No sign of dirtiness was found and the level of molds and yeasts encountered in both flours complies with the legal standards in effect in the country. We conclude that although the multimixtures present good levels of nutrients, they are highly susceptible to decomposition.
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PMID:Study of chemical characteristics and nutritional quality of two food-subproduct flours--multimixture. 1061 55

Small GTPase RhoA regulates signal transduction from receptors in the membrane to a variety of cellular events related to cell morphology, motility, cytoskeletal dynamics, cytokinesis, and tumour progression, but it is unclear how RhoA regulates intracellular membrane dynamics of lysosomes. We showed previously by confocal immunofluorescence microscopy that the transfection of dominant active RhoA in MM1 cells causes the dispersal translocation of lysosomes stained for cathepsin D throughout the cytoplasm. Y-27632, a selective inhibitor of p160ROCK, impeded the cellular redistribution of lysosomes and promoted reclustering of lysosomes toward the perinuclear region. Here we have further investigated whether the acidic lysosomal vesicles dispersed throughout the cytoplasm are applied to the early endosomes in the endocytic pathway, and we demonstrate that the dispersed lysosomes were accessible to endocytosed molecule such as dextran, and their acidity was not changed, as determined by increased accumulation of the acidotropic probe LysoTracker Red. Brefeldin A did not induce the tabulation of these dispersed lysosomes, but it caused early endosomes to form an extensive tubular network. The dispersed lysosomes associated with cathepsin D and LIMPII were not colocalized with early endosomes, and these vesicles were not inaccessible to the endocytosed anti-transferrin receptor antibody. Moreover, wortmannin, an inhibitor of phosphatidylinositol 3-kinase, induced a dramatic change in LIMPII-containing structures in which LIMPII-positive swollen large vacuoles were increased and small punctate structures disappeared in the cytoplasm. These swollen vacuoles were not doubly positive for LIMPII and transferrin receptor, and were not inaccessible to the internalized anti-transferrin receptor antibody. Therefore, our novel findings presented in this paper indicate that RhoA activity causes a selective translocation of lysosomes without perturbing the machinery of endocytic pathway.
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PMID:A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells. 1258 97