Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
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Query: UMLS:C0847097 (
acidity
)
15,165
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Partition coefficients for compounds (solutes) from water to isopropyl myristate,
IPM
, have been obtained from the literature, either as directly determined partition coefficients or from solubilities in water and in
IPM
. The general solvation equation of Abraham has been applied to 141 such partition coefficients, as logPipm, and it is shown that the main solute factors that influence partition are dipolarity/polarisability, hydrogen bond
acidity
and hydrogen bond basicity that reduce partition, and volume that increases partition. These factors are quantitatively very similar to those that influence partition in the water to olive oil system, and indicate that
IPM
has the expected behaviour of a long chain, hydrophobic ester. It is shown that the water to
IPM
system is a poor model for partition between water and human stratum corneum and for permeation from water through human skin.
...
PMID:Characterisation of the water-isopropyl myristate system. 1581 36
