Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The investigations were carried out on 7 wethers with cannulated fistulas of the "small" abomasum and rumen. In two series of experiments the optimal dose of one of the tested analogues of PGF 2 alpha (Estrumate 3-4 microgram/kg, Lutalyse 130-170 microgram/kg of body weight) was used. It was found the Estrumate in relation to Lutalyse caused a highly statistical significant rise (P less than 0.01) in the volume of secreted juice, free HCl, and total acidity in the same sheep. The specific activity (Anson mU/ml) increased more after Lutalyse (P less than 0.01) than after Estrumate injection. This analogue also caused significant (P less than 0.02) changes in the total activity (specific activity X juice volume of this sample). The obtained results expressed in per cent indicate that Estrumate exerts a greater effects on the parietal cells in the abomasal mucosa in sheep and Lutalyse stimulates more strongly the chief cells, as reflected in increased proteolytic power of the studied juice.
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PMID:Comparison of the effects of two prostaglandin F2 alpha analogues-estrumate and lutalyse on the volume, activity, and proteolytic power of the abomasal juice in sheep. 675 33

In the experiments carried out on 3 sheep (males) it was demonstrated that intramuscular administration of Lutalyse in optimal doses (130-170 g/kg of body weight) caused a rise in the volume of juice, the amount of free HCl, and the value of total acidity, as well as an increase in the specific activity (Anson's milliunits in ml) and total activity (specific activity multiplied by juice volume in each sample). It was found that Lutalyse (an analogue of PGF2 alpha) increased the secretory activity of the glandular cells of the abomasum and stimulated particularly powerfully the chief cells, with consequent rise in the proteolytic power of the juice.
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PMID:Investigations of the effect of F2 alpha-prostaglandin--lutalyse on the volume of sheep abomasal juice, its acidity and proteolytic power. 739 41