Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Milk production of dairy cows in six herds was increased by approximately 15% by the administration of recombinantly derived bST in a sustained-release vehicle (somidobove, Eli Lilly/Elanco, Indianapolis, IN) at 28-d intervals, which commenced at 52 to 104 d postpartum. Milk composition, acidity, flavor, and growth of commercial lactic acid starter cultures were unaffected by somidobove treatment. No adverse effect upon health (metabolic diseases, mastitis) and reproduction was noted. Blood glucose, FFA, aspartate aminotransferase, alanine aminotransferase, Ca, Na, and K were unaffected by the application of somidobove. Somidobove did not affect the appearance of the organs of cows at slaughter; however, somidobove-treated cows had less subcutaneous and omental adipose tissue than controls. Cultured explants of subcutaneous adipose tissue of treated cows showed significantly lower lipogenesis from acetate than controls. The release of FFA was not affected by treatment. Recombinantly derived somidobove has been judged in Czechoslovakia to be effective and safe for cows and the environment. Edible products from the treated cows are safe for human consumption.
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PMID:Impact of bovine somatotropin on dairying in eastern Europe. 179 65

The effect of gastric pH on the viability and virulence of Yersinia enterocolitica O:8 after exposure to sublethal concentrations of copper and chlorine was determined in mice. Viability and injury were assessed with a nonselective TLY agar (tryptic soy broth containing lactose, yeast extract, and agar) and two selective media, TLYD agar (TLY agar plus sodium deoxycholate) and CIN agar (cefsulodin-Irgasan-novobiocin agar). Both copper and chlorine caused injury which was manifested by the inability of the cells to grow on selective media. CIN agar was more restrictive to the growth of injured cells than TLYD agar. Injury of the exposed cells was further enhanced in the gastric environment of mice. Besides injury, the low gastric pH caused extensive loss of viability in copper-exposed cells. Lethality in the chlorine-exposed cells was less extensive, and a portion of the inoculum (5.2 X 10(5) of 1 X 10(7) inoculated cells) reached the small intestine 5 min postinoculation. No adverse effect on the injured cells was apparent in the small intestine, and a substantial revival (approximately 70%) of the injury occurred in 3 to 4 h after intraluminal inoculation. The virulence of chlorine-stressed Y. enterocolitica in orally inoculated mice was similar to that of the control culture, but copper-stressed cells showed reduced virulence. Virulence was partly restored by oral administration of sodium bicarbonate before the inoculation of copper-exposed cells. Neutralization of gastric acidity had no effect on the virulence of the control or chlorine-stressed cells. The results of this study indicate that the extensive injury caused by the low gastric pH does not affect the virulence potential of chlorine-exposed cells. However, extensive cell death in the mouse stomach is responsible for the reduced virulence of the copper-stressed bacteria.
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PMID:Survival and virulence of copper- and chlorine-stressed Yersinia enterocolitica in experimentally infected mice. 366 14