Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One of the major unanswered questions regarding the presence of Listeria monocytogenes in foods is how many cells must be ingested in order to cause illness. To answer this question, studies were undertaken by using Macaca fascicularis (cynomolgus monkey) as an animal model. Healthy nonhuman primates were dosed with various concentrations of L. monocytogenes suspended in sterile whole milk. Final concentrations of 10(5), 10(7), and 10(9) total cells of the organism were used; a control was also included. Blood samples, as well as fecal and nasal specimens, were taken at various time intervals. Only animals that received 10(9) cells of L. monocytogenes became noticeably ill, with symptoms of septicemia, irritability, loss of appetite, and occasional diarrhea. Monkeys that received 10(7) and 10(9) cells shed L. monocytogenes in the feces for approximately 21 days. In monkeys that received the dose of 10(9) cells, severe lymphopenia and neutrophilia occurred within 48 h. In a separate trial, monkeys received Maalox to reduce the gastric acidity of the stomach. However, no substantial differences were observed between Maalox-treated and control monkeys.
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PMID:Feeding trials of Listeria monocytogenes with a nonhuman primate model. 177 70

Cachexia is a pathological state characterized by weight loss and protein mobilization during various diseases. Nutritional supplementation or appetite stimulants are unable to restore the loss of lean body mass. Agents interfering with TNF-alpha have not been very successful to date. Only eicosapentaenoic acid was able to interfere with the action of proteolysis-inducing factors. An acceleration of proteolysis and branched-chain amino acid oxidation was correlated with chronic metabolic acidosis. Therefore, we suggest here that the main cause of cachexia is the increased acidity of the body fluids, which results in a higher and non-specific proteolysis of muscle proteins. Moderate hypoxia might be close related to lactic acid production within the whole body, not only in the cancer cells. Anorexia seems to be a consequence, but a cause of cachexia: the cachectic patients are in fact well fed, unfortunately they use fatty acids from their fat and glucose via muscle proteins, amino acids, alanine, and lactic acid. Our hypothesis is consistent with the most findings reported in literature and opens new ways for cachexia prevention and therapy, such as pH correction or higher oxygenation.
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PMID:Chronic metabolic acidosis may be the cause of cachexia: body fluid pH correction may be an effective therapy. 1818 Jan 10

It has been shown that small amounts of the digestive secretions normally present in the duodenum regurgitate into the stomach following operative anastomosis between the stomach and the upper intestinal tract. As the duodenal contents are alkaline in reaction this reflux is thought by many to result in a decrease in the acidity of the gastric contents. The purpose of the investigations reported here has been to determine the effect of bile on the acid chyme of the stomach. By means of a cholecystgastrostomy with ligation and division of the common bile duct in six dogs the bile was diverted from the duodenum into the stomach. The secretion of gastric juice and the acidity of the gastric contents throughout the period of digestion were followed before and after the anastomoses. For this purpose three of the dogs were provided with Pawlow stomach pouches. In the three remaining animals the test meals were recovered by using apomorphin injections. The results from the two series of experiments agree. They indicate, at least with a diet of meat and water, that bile when it is present in the stomach throughout the course of digestion has no appreciable effect on the acidity of the gastric contents. While the anastomosis of the gall bladder to the stomach occasioned some temporary anorexia and vomiting in two of the dogs, the four remaining animals bore the operation well. Three or four weeks subsequent to the operation the digestion and the nutrition appeared normal in each instance. Postmortem examinations revealed no pathological changes in the gastric mucosa.
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PMID:AN EXPERIMENTAL STUDY OF THE EFFECT OF CHOLE-CYSTGASTROSTOMY ON GASTRIC ACIDITY. 1986 68

Ginger is an herbaceous perennial rhizome traditionally used in culinary for its flavor and pungency. It is also used as carminative, stimulant and for its anti-emetic properties due to gingerols and shogaols. Appetite loss is one of the problems faced at high altitudes and the appetizers based on ginger may be useful for appetite stimulation. The fruit munch and ginger munch based on fresh and powdered ginger respectively were developed using response surface methodology (RSM). The sensory score, acidity and total sugars were the responses in the central composite designs of experiments with three independent variables. The ingredients raisins, dates, almonds were pre-processed by frying in stable fat while juice was extracted from pseudolemon and lemon. The optimized composition of ingredients was processed further through concentration. The carbohydrate rich munches had vitamin C content in the range 37-43mg/100g and calorific value of about 90kCal per munch. The munches packed in metalized polyester pouches had a shelf life of 8 months at ambient conditions (18-33 degrees C) as well as at a fixed temperature of 37 degrees C storage.
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PMID:Development of ginger based ready-to-eat appetizers by response surface methodology. 2041 39