Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Propyl-methylenedioxyindene (pr-MDI; 30 mg/kg, i.p.), an intracellular calcium antagonist, significantly reduced the number and size of erosions per stomach induced by cold-restraint stress by 69% and 86%, respectively. Our previous findings indicate that the antiulcer activity of pr-MDI is highly correlated with its inhibitory effect on gastric motor activity. Since central TRH is suggested as the brain mediator responsible for cold-restraint stress gastric ulcers in rats, the inhibitory action of pr-MDI was evaluated in the TRH-induced gastric lesion model. Pr-MDI (30 mg/kg) did not reduce the gastric erosions induced by intracisternal administration of 100ng RX77368, a stable thyrotropin-releasing hormone (TRH) analogue, even though it abolished the RX77368-induced stimulation of gastric emptying, gastric acidity, and acid output. Since pr-MDI (30 mg/kg, i.p.) significantly inhibited the stimulation of gastric motility by both cold-restraint stress and TRH, but only cold-restraint stress-induced gastric erosions were effectively reduced by the drug, the present findings suggest a possible dissociation between the ulcerogenic mechanisms of cold-restraint stress and intracisternal administration of TRH.
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PMID:Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene. IV. Effects on gastric lesions in rats induced by cold-restraint stress and thyrotropin-releasing hormone. 212 9

Precise determination of pH values with an instrument-free mode is challenging and practical in industry processes, life science, and environmental monitoring. Here, taking advantage of the intramolecular charge transfer process, we construct a cellulose-based superior pH sensor, Phen-MDI-CA, which contains a highly sensitive, pH-responsive, and extended conjugation structure by combining phenanthroline moiety as a chromophore with urea group as a bridge. The resultant Phen-MDI-CA can precisely and visually determine pH values under extreme acidic and strong basic environments, depending on the different colors. In visible light mode, Phen-MDI-CA can readily discriminate the pH values of 14.0, 13.0, 12.0, and 11.0 and distinguish pH 2.0 from 1.0 by the naked eye. In fluorescent mode, Phen-MDI-CA can recognize more accurate pH values of pH 11.6-13.2 at a 0.2-0.4 pH interval by the high-contrasting color change. After addition of pH-irresponsive dyes as the reference, the corresponding ratiometric systems exhibit different colors at a 0.2-0.4 pH interval during the pH values of 11.0-14.0 and 1.0-2.0. Benefiting from the excellent formability, the Phen-MDI-CA was readily fabricated into pH test strips by coating method. To our knowledge, this is the first study to monitor extreme acidity and strong basicity in such precise pH values with an instrument-free mode.
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PMID:Visual and Precise Detection of pH Values under Extreme Acidic and Strong Basic Environments by Cellulose-Based Superior Sensor. 3064 95