Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Determination was made of in situ gastric pH during early morning in fasting state (basal pH) by using wired glass electrodes, and results obtained were analyzed. Analysis of the pattern of variation in intragastric pH at night revealed no substantial difference between normal subjects and patients with peptic ulcer but a tendency to be lower in the latter group. It was also shown that sleeping waves appeared in the electroencephalogram in association with the increase in intragastric pH during sleep at night. The basal pH value was 5.4 +/- 2.1 in patients with gastric cancer, 3.0 +/- 2.2 in those with gastritis, 2.4 +/- 1.9 in those with gastric ulcer, 1.7 +/- 0.2 in normal subjects and 1.3 +/- 0.6 in patients with duodenal ulcer. In gastric ulcer patients more anal site of ulcer lesion was associated with lower mean age of the patients and higher incidence of intestinal metaplastic gastritis of the antral or non-metaplastic type. In patients who underwent partial gastrectomy for peptic ulcer, the pH value in the remnant stomach tended to become higher with the lapse of time in all cases, being constant at about 3 months postoperatively. The decrease in gastric acidity at 12 months after operation was incomplete in patients who underwent emergency gastrectomy for perforated duodenal ulcer but satisfactory in those who underwent selective vatotomy and anterectomy as elective operations.
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PMID:A study of intragastric pH in patients with peptic ulcer--with special reference to the clinical significance of basal pH value. 732 83

We reviewed 254 consecutive gastroduodenal operations done at Charity Hospital of Louisiana in New Orleans between June 1974 and June 1977. Forty-one septic complications occurred in 30 patients, for an overall infection rate of 11.8%. Statistically higher infection rates followed operations for bleeding gastric or duodenal ulcer, obstructed duodenal ulcer, gastric ulcer, and gastric malignancy when compared to those done for chronic uncomplicated ulcer or perforated duodenal ulcer. Of these 30 patients, 22 had a compromise of either gastric acidity or motility at the time of operation. These two factors appear to be most significant in controlling the organisms which reach the stomach from swallowed saliva or by reflux through the pylorus. The organisms most frequently causing infection after gastroduodenal operations are endogenous to the stomach and include aerobic enteric gram-negative bacilli and oral, penicillin-sensitive anaerobes. Exogenous bacteria such as Staphylococcus aureus are a less frequent cause of infection after these operations.
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PMID:Sepsis after gastroduodenal operations: relationship to gastric acid, motility, and endogenous microflora. 738 47

The efficacy of truncal vagotomy combined with pyloroplasty has been studied in 56 patients, divided into the following groups: Group I-29 patients submitted to bilateral truncal vagotomy (BTV) and pyloroplasty, as the method of treatment to solve the problem of perforated duodenal ulcer (initial and retrospective phase of study). Group II-With 11 patients, who underwent the same operation as those in Group I but with the surgeon's knowledge of the results of phase I and also awareness of the laboratory control of its surgery (prospective phase). Group III-A control Group of 16 patients, with chronic duodenal ulcer submitted to a routine proximal gastric vagotomy (superselective or hyperselective vagotomy). All of the patients were clinically evaluated and all of them have done acid secretion studies (Kay and Sham-Feeding test). Basal acid output (BAO), maximum acid output after Sham-Feeding (PAOsf), and pentagastrine (PAOpg), were determined in order to control the efficacy of vagotomy. In group III, results were compared with those obtained pre-operatively. In Group I, 48.27% of patients had a PAOsf higher than 4 mEq/hour-value which has been considered the maximum level of normality after complete BTV without gastric resection. In Group II, the number of patients with incomplete vagotomy decrease to 18.18%. In Group III, all the patients had a PAOsf lower than 4 mEq/hour and 83.81% of acidity reduction after Sham-Feeding test, in comparision with the pre-operative values.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Quality control of vagotomy in duodenal ulcer perforation]. 771 9