Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present ethnobotanical exploratory study embodies the folk medicinal uses of certain important medicinal plants by tribals of bastar district in Madhya Pradesh state of India. Twenty seven medicinal plants form diverse families have been covered being therapeutically used against different diseases such acidity, debility, diabetes, male and female weakness, fistula, migraine and skin diseases etc. How the tribal folks consider the mode of drug administration and application in different ailments has been ailments has been elaborately emphasized.
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PMID:Prophylactic uses of some medicinal plants in bastar district of madhya pradesh. 2255 57

Acid-sensing ion channels (ASICs) are widely expressed in the body and represent good sensors for detecting protons. The pH drop in the nervous system is equivalent to ischemia and acidosis, and ASICs are very good detectors in discriminating slight changes in acidity. ASICs are important pharmacological targets being involved in a variety of pathophysiological processes affecting both the peripheral nervous system (e.g., peripheral pain, diabetic neuropathy) and the central nervous system (e.g., stroke, epilepsy, migraine, anxiety, fear, depression, neurodegenerative diseases, etc.). This review discusses the role played by ASICs in different pathologies and the pharmacological agents acting on ASICs that might represent promising drugs. As the majority of above-mentioned pathologies involve not only neuronal dysfunctions but also microvascular alterations, in the next future, ASICs may be also considered as potential pharmacological targets at the vasculature level. Perspectives and limitations in the use of ASICs antagonists and modulators as pharmaceutical agents are also discussed.
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PMID:Acid-Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System Diseases. 2692 Jun 89