Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0847097 (acidity)
 15,165 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although numerous NSAIDs are available for use in the management of rheumatic disease, most of the members of this large class of drugs possess very similar characteristics. The great majority are acidic compounds. The acidity of the drugs allow distribution not only into inflamed tissues but also the kidneys and gastric mucosa. It is likely that these compounds produce anti-inflammatory analgesia by inhibiting prostaglandin synthesis. As a result of these similarities, NSAIDs have in general relative similar efficacy and toxicity when used in appropriate dosages. Common adverse effects include dyspepsia, gastritis, mucosal ulcers, interstitial nephritis and acute renal failure. Most of the adverse effects associated with the clinical use of these drugs are related to their effect on prostaglandin production. In some susceptible individuals, the inhibition of prostaglandin synthesis may result in a potentially fatal bronchospastic episode. Most clinical trials fail to consistently distinguish between NSAIDs. Patients however often develop distinct preferences for certain NSAIDs. The reason for this is still obscure but may reflect subtle pharmacological differences between these drugs. NSAIDs with short half-lives are quite effective on an 8 or 12 hourly dosage regimen. Compounds with longer half-lives may be associated with accumulation in the elderly and hence a higher risk of toxicity. The use of NSAIDs in the management of rheumatic disease should therefore be highly individualised.
 ...
PMID:NSAIDS--a consideration of their efficacy and toxicity. 265 71

By the employment of what we are pleased to call a "basic diet," the urinary acidity may be easily reduced to a pH of 7.00 or better. On such diets patients with chronic interstitial nephritis appear to improve, as evidenced by a decrease in blood pressure, albumin and casts in the urine and other symptoms of nephritis and arterial hypertension.
 ...
PMID:THE USE OF BASIC DIETS IN THE TREATMENT OF NEPHRITIS. 1873 37