Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: UMLS:C0752347 (Dementia with Lewy bodies)
1,653 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein alpha-synuclein 332 synuclein 206 Sep 95 ubiquitin 86 amyloid precursor protein 76 MRI 51 Mol 37 olfactory 36 prion 36 dopamine transporter 35 tau protein 33 TGF-beta 31 TDP-43 28 glucocerebrosidase 28 APOE 27 tyrosine hydroxylase 24 axonal 24 acetylcholinesterase 23 apolipoprotein E 23 FDG 23 proteasome 23 LBD 20 SNCA 20 REM 20 CA2 18 LRRK2 18 Cholinesterase 18 FTD 18 CIT 18 She 17 CSF 17 amyloid beta 14 dream 14 parkin 13 prion protein 13 14-3-3 13 APP 13 MSA 12 CA1 12 glial fibrillary acidic protein 12 Ubiquitin 11 PSP 11 PrP 10 Apolipoprotein E 10 GBA1 10 beta-synuclein 9 neuronal protein 9 PSEN1 8 DNA-binding protein 8 LC3 8 synaptophysin 8 Parkin 8 ALS 7 esterase 7 p62 7 choline acetyltransferase 7 alpha synuclein 7 endoplasmic reticulum 7 fused 6 PARK2 6 leucine-rich repeat kinase 2 6 PARK8 6 brain-derived neurotrophic factor 6 DJ-1 6 ATP 6 SDS 6 CBD 6 GRN 6 cystatin C 6 cathepsin D 5 CYP2D6 5 insulin 5 IL-6 5 huntingtin 5 crystallin 5 catalase 5 CA3 5 C9orf72 5 TPPP/p25 5 ferritin 5 E3 ubiquitin ligase 5 PSEN2 4 progranulin 4 MAP2 4 ANOVA 4 butyrylcholinesterase 4 neurofilament protein 4 TNF 4 NMR 4 SNCB 4 microtubule-associated protein 4 muscarinic receptor 4 NMDA receptor 4 tumor necrosis factor 4 PINK1 4 MAO-B 4 GSH 4 APO 4 caspase-3 4 14-3-3 protein 4 ERK 4 neurotrophic factor 4 synphilin-1 4 apolipoprotein 4 ubiquitin C-terminal hydrolase 4 SOD 4 PGP 9.5 4 DAT 4 Iba1 4 with Parkinsonism 3 SNAP 3 collagen 3 5-HT2A 3 NUB1 3 TAU 3 HLA-DR 3 superoxide dismutase 3 metabotropic glutamate receptor 3 amyloid protein 3 FUS 3 TAR DNA-binding protein 43 3 cytokine 3 ERK1 3 gamma-synuclein 3 enolase 3 calbindin 3 p38 3 p53 3 MRS 3 CA4 3 GSD 3 PARK7 3 COMT 3 PDGF 3 Bcl-2 3 TPPP 3 interferon 3 SORL1 3 UTR 3 MAPK 3 CD4 3 Visinin-like protein 1 3 GABA 3 AChE 3 extracellular protein 3 NACP 3 glutamate receptor 3 BACE1 2 CYP3A4 2 dentatorubral-pallidoluysian atrophy 2 housekeeping 2 ART 2 proline-rich 2 hemoglobin 2 cytochrome P450 2 Proteinase 2 MAP kinase 2 alpha, beta 2 nerve growth factor 2 vesicular monoamine transporter 2 2 more...

Disease Dementia with Lewy bodies 1653 dementia 913 Alzheimer's disease 903 Parkinson's disease 848 parkinsonism 283 cognitive impairment 193 hallucinations 178 progressive supranuclear palsy 150 depression 75 psychosis 68 delusions 56 Pick's disease 53 amyotrophic lateral sclerosis 48 REM sleep behavior disorder 43 plaque 42 Creutzfeldt-Jakob disease 39 Huntington's disease 36 behavior disorder 34 PDD 30 vascular disease 29 aphasia 25 delirium 23 movement disorder 23 encephalopathy 21 apraxia 21 Multiple system atrophy 21 schizophrenia 21 brain atrophy 20 LBD 20 sleep disorders 19 Gaucher disease 18 motor neuron disease 18 Vascular dementia 17 dysautonomia 16 memory impairment 15 Down syndrome 15 stroke 14 confusion 14 hypertension 12 akinesia 12 MSA 12 PSP 11 pneumonia 11 parasomnia 11 FTLD 11 PAF 10 dysphagia 10 Frontotemporal dementia 10 neurological disease 10 senile dementia 10 hydrocephalus 9 sleep disturbances 8 disinhibition 8 multiple sclerosis 8 dyskinesia 7 major depressive disorder 7 agnosia 7 sleep apnea 7 incontinence 7 PARK2 6 diabetes 6 cognitive deficit 6 bipolar disorder 6 neuroblastoma 6 amyloidosis 6 amnesia 6 SDS 6 epilepsy 6 CJD 6 mental illness 5 multiple disorders 5 CAA 5 disorientation 5 cancer 4 spongiform encephalopathy 4 Pure autonomic failure 4 Cranial nerves 4 CAA 4 olivopontocerebellar atrophy 4 aggression 4 leukoencephalopathy 4 encephalitis 4 Corticobasal degeneration 4 ventricular dilatation 4 Posterior 4 PARK8 4 restless legs syndrome 4 Cranial nerves 4 Bielschowsky 4 cold 4 GSH 4 cardiovascular disease 4 cognitive disorder 4 narcolepsy 4 incontinence 4 hypothyroidism 3 PARK7 3 Capgras syndrome 3 migraine 3 mania 3 FUS 3 primary lateral sclerosis 3 posttraumatic stress disorder 3 dehydration 3 sarcoma 3 degenerative disease 3 Hallervorden-Spatz disease 3 Neurodegenerative Disorders 3 BPSD 3 B-cell lymphoma 3 neurogenic bladder 3 aggressiveness 3 bronchopneumonia 3 tumor 3 MRS 3 scrapie 3 renal failure 3 atherosclerosis 3 Epstein 2 myocardial infarction 2 Tourette syndrome 2 language disorder 2 hemiparesis 2 bradyarrhythmia 2 myelodysplastic syndrome 2 ICD 2 myasthenia gravis 2 suicide attempts 2 cytomegalovirus 2 hyperlipidemia 2 hallucinosis 2 muscular atrophy 2 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 2 immunodeficiency 2 pseudobulbar palsy 2 chronic obstructive pulmonary disease 2 Pseudodementia 2 agranulocytosis 2 agraphia 2 stereotypies 2 paranoia 2 metabolic syndrome 2 visual dysfunction 2 Whipple's disease 2 kuru 2 anemia 2 multi-infarct dementia 2 Dementia in Parkinson's disease 2 Hashimoto's thyroiditis 2 MDS 2 mole 2 presenile dementia 2 ischemia 2 mole 2 Progressive dementia 2 amnesic syndrome 2 cerebral infarction 2 celiac disease 2 SPM 2 varices 2 more...

Symptom tremor 65 bradykinesia 24 agitation 21 dystonia 21 visual hallucination 20 apathy 19 myoclonus 14 memory loss 11 constipation 10 syncope 10 ataxia 10 sleepiness 9 anosmia 6 weakness 6 pain 5 fatigue 4 Psychiatric symptoms 4 catatonia 4 cerebellar ataxia 3 nausea 3 chorea 3 insomnia 3 dizziness 3 dysarthria 3 vomiting 3 seizures 2 thinning 2 spasticity 2 respiratory distress 2 anorexia 2 Visual symptoms 2 muscle rigidity 2 Behavioral symptoms 2 Retropulsion 2 ophthalmoplegia 2 paresis 2 blepharospasm 2 motor symptom 2 headache 2 dysuria 2 Involuntary Movement 1 Postural tremor 1 Rest tremor 1 Poor sleep 1 snoring 1 hypersomnia 1 asterixis 1 Fluctuation 1 Extrapyramidal rigidity 1 athetosis 1 personality change 1 spasm 1 metamorphopsia 1 paraparesis 1 Gastrointestinal symptoms 1 physical symptom 1 eds 1 Hemiballism 1 numbness 1 stridor 1 leg pain 1 lethargy 1 Depressive symptoms 1 stigma 1 auditory hallucination 1 cough 1 abnormal gait 1 vertigo 1 diarrhea 1 cachexia 1 abdominal pain 1 sneezing 1 clumsiness 1 dyspnea 1

Drug CSF 17 Donepezil 9 Parkin 8 Parkin 8 Frontal 8 ROC 5 vitamin E 4 lysine 4 Spectrum 2 ascorbate 2 MDS 2 Heme 2 Fluorescein 2 Leaf 2 Portal 2 Azilect 2 Paraffin 2 ROS 1 lactose 1 Xanthium 1 Mazindol 1 Rotigotine 1 Triclosan 1 Vitamin E 1 CFT 1 Phenytoin 1 HCH 1 Vitamin B 1 caffeine 1 NADH 1 Monit 1 IL-2 1 PPA 1 Tianeptine 1 Gluconolactone 1 Escitalopram 1 Pramipexole 1 Modafinil 1 Pramipexole 1 Exametazime 1 Vitamin B12 1 Lovastatin 1 Aricept 1 citric acid 1 ETS 1 Domin 1 IPD 1

Enzyme acetylcholinesterase 73 cholinesterase 57 proteasome 25 tyrosine hydroxylase 23 glucocerebrosidase 22 mitogen-activated protein kinase 11 ERK 10 proteinase K 8 choline acetyltransferase 7 protein kinase 7 complex I 6 monoamine oxidase 6 superoxide dismutase 6 catalase 5 cathepsin D 4 DAT 4 isopeptidase 4 caspase-3 4 enolase 3 focal adhesion kinase 3 Thy1 3 trypsin 3 phospholipase A2 2 prolyl endopeptidase 2 protein phosphatase 2A 2 calcineurin 2 cathepsin B 2 protein kinase C 2 tryptophan hydroxylase 2 phospholipase C 2 GSK 2 CYP3A4 2 MEK 2 gamma-glutamyl transpeptidase 2 PARP 2 glutathione peroxidase 2 MEKK1 2 cytochrome oxidase 1 CPT 1 ornithine decarboxylase 1 AMP-activated protein kinase 1 ACE 1 glutathione reductase 1 caspase-2 1 CPR 1 ubiquitin-protein ligase 1 pyruvate dehydrogenase 1 thrombin 1 alanine aminotransferase 1 hexosaminidase 1 caspase-9 1 insulin-degrading enzyme 1 kallikrein 1 beta-secretase 1 diaphorase 1 IKK 1 cathepsin H 1 pyruvate dehydrogenase 1 PTA 1 ATPase 1 tryptase 1 caspase-2 1 GRK2 1 ACS 1 GRK5 1 chymotrypsin 1 NOS 1 CaMKII 1 endothelin-converting enzyme 1 CPT 1 phospholipid:diacylglycerol acyltransferase 1 beta-galactosidase 1 NADPH oxidase 1 creatine kinase 1 pyruvate dehydrogenase 1 alpha-mannosidase 1 neurosin 1 DAP II 1 heparinase 1 mannanase 1 NADPH oxidase 1 BAL 1 CPT 1 mu-calpain 1

Compound Clin 105 Dec 97 DNA 29 iron 26 glucose 22 CIT 18 CIT 18 calcium 16 glutamate 14 L-DOPA 13 oxygen 12 Neuronal 12 PSP 11 Ubiquitin 10 silver 10 hydrogen 9 His 9 DSM 9 iodine 8 formic acid 7 formic acid 7 formic acid 7 formic acid 7 formic acid 7 formic acid 7 formic acid 7 Dopamine 7 serine 7 Rivastigmine 7 formic acid 7 formic acid 7 formic acid 7 Clozapine 6 ATP 6 tyrosine 6 methionine 6 water 6 TDP 6 SDS 6 GSH 5 copper 5 manganese 5 GSH 5 MPTP 5 NMDA 4 DAT 4 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4 lysine 4 Memantine 4 Cereb 4 galanthamine 4 TNF 4 Quetiapine 4 nitrogen 4 ACh 4 galactose 4 cysteine 4 5-HT 4 APO 4 threonine 4 valine 4 CAA 4 methyl carbamate 3 formaldehyde 3 leucine 3 phosphate 3 noradrenaline 3 GABA 3 GABA 3 alanine 3 creatinine 3 sulfate 3 Hematoxylin 3 sodium 3 coenzyme Q10 2 zinc 2 quinazoline 2 Heme 2 urea 2 salt 2 nitric oxide 2 HVA 2 Asp 2 Corticosterone 2 aldehyde 2 TOF 2 guanidine 2 Eosin 2 Retinal 2 SPM 2 aluminum 2 potassium 2 Haloperidol 2 Haloperidol 2 aldehyde 2 2-nonenal 2 cAMP 2 Triton X-100 2 quinazoline 2 benzamide 2 arginine 2 PGA 2 Eosin 2 Ceftriaxone 2 HMM 1 Amantadine 1 GMP 1 PDP 1 IPD 1 DCL 1 ATF 1 DIC 1 Lovastatin 1 THE 1 CPT 1 5-HIAA 1 NADH 1 Gluconolactone 1 CoA 1 Ile 1 Elan 1 TCP 1 GTP 1 Lithium 1 BMC 1 Thioflavin T 1 CoQ 1 hexadecanedioic acid 1 cyanide 1 TCP 1 Trehalose 1 mercury 1 Baicalein 1 Amantadine 1 ethyl methylcarbamate 1 dUTP 1 Glycogen synthase 1 Melatonin 1 acridine 1 Tuberin 1 PPA 1 Montelukast 1 Panam 1 Ara-C 1 CHIP 1 Candesartan cilexetil 1 Lactate 1 Risperidone 1 Xanthine 1 glutamine 1 Dopa 1 GSSG 1 Aripiprazole 1 Zolpidem 1 Crocin 1 Cocaine 1 TCP 1 PEG 1 ACS 1 glutamic acid 1 more...

---