Gene/Protein
Disease
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Enzyme
Compound
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Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0752347 (
Dementia with Lewy bodies
)
1,653
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Polyamines are small cationic molecules that in adult brain are connected to neuronal signaling by regulating inward-rectifier K(+)-channels and different glutamate receptors. Antizyme inhibitors (AZINs) regulate the cellular uptake of polyamines and activate ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine synthesis. Elevated levels of ODC activity and polyamines are detected in various brain disorders including stroke and Alzheimer's disease (AD). We originally reported a novel brain- and testis-specific AZIN, called
AZIN2
, the distribution of which we have now studied in normal and diseased human brain by in situ hybridization and immunohistochemistry. We found the highest accumulation of
AZIN2
in a pearl-on-the-string-like distribution along the axons in both the white and gray matter.
AZIN2
was also detected in a vesicle-like distribution in the somas of selected cortical pyramidal neurons. Double-immunofluorescence staining revealed co-localization of
AZIN2
and N-methyl D-aspartate-type glutamate receptors (NMDARs) in pyramidal neurons of the cortex. Moreover, we found accumulation of
AZIN2
in brains affected by AD, but not by other neurodegenerative disorders (CADASIL or
Lewy body disease
). ODC activity is mostly linked to cell proliferation, whereas its regulation by
AZIN2
in post-mitotically differentiated neurons of the brain apparently serves different purposes. The subcellular distribution of
AZIN2
suggests a role in vesicular trafficking.
...
PMID:Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease. 1983 40
