Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0752347 (
Dementia with Lewy bodies
)
1,653
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression patterns of alternatively spliced forms of the
CYP2D
(6, 7, 7A, 7B) gene were analyzed in the brains of individuals with
Lewy body disease
(
LBD
) and correlated with CYP2D6 polymorphisms. Five different alternatively spliced transcripts were identified. The most common was the deletion of exon 6 (87.3% of cases), followed by a 91-base pair fragment deletion at the 3' end of the gene (63.9% of cases). There was no correlation between the polymorphisms in the CYP2D6B gene or presence of
LBD
and these five alternatively spliced transcripts. Susceptibility to
LBD
may occur through mechanisms other than altered mRNA splicing of the CYP2D6 gene.
...
PMID:Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders. 1053 38
