Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0752347 (Dementia with Lewy bodies)
 1,653 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The article presents diagnostic criteria for dementia associated with diffuse Lewy body disease (DLBD) elaborated by the group of investigators from Nottingham (Byrne et al. 1991). These criteria allow to make the diagnosis of "probable" or "possible" dementia associated with DLBD. With certainty this form of dementia can only be diagnosed by neuropathological examination which reveals diffuse cortical Lewy bodies. At present there is no agreement whether DLBD is a variant of Alzheimer's disease or a separate nosological entity--the second commonest cause of dementia. The main clinical feature of DLBD is coexistence of dementia and symptoms of parkinsonian syndrome. The other important feature which differentiates between DLBD and other forms of dementia is a very considerable early fluctuation of cognitive state. Psychotic symptoms in the course of DLBD--visual and auditory hallucinations, delusions and depression--are common. At present treatment of DLBD is unknown. Treatment of psychotic symptoms is difficult because of the presence of parkinsonism.
Psychiatr Pol
PMID:[Dementia in diffuse Lewy body disease]. 765 84

We introduce a case of diffuse Lewy body disease (DLBD) diagnosed post mortem. Clinically patient was assessed as severe Alzheimer's disease. Typical picture of DLBD was disclosed immunohistochemically; anti-ubiquitin staining revealed numerous temporal, neocortical Lewy bodies, CA2/3 alterations and scanty senile plaques.
Neurol Neurochir Pol
PMID:[A case of disseminated Lewy bodies disease: clinical and neurological finding]. 904 69