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Query: UMLS:C0752347 (
Dementia with Lewy bodies
)
1,653
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Dementia with Lewy bodies
(
DLB
) is the second most common degenerative dementia of the central nervous system. The technique
18
F-fluorodeoxyglucose positron emission tomography (
18
F FDG PET) was used to investigate brain metabolism patterns in
DLB
patients. Conventional statistical methods did not consider intern metabolism transforming connections between various brain regions; therefore, most physicians do not understand the underlying neuropathology of
DLB
patients. In this study,
18
F FDG-PET images and graph-theoretical methods were used to investigate alterations in whole-brain intrinsic functional connectivity in a Chinese
DLB
group and healthy control (HC) group. This experimental study was performed on 22
DLB
patients and 22 HC subjects in Huashan Hospital, Shanghai, China. Experimental results indicate that compared with the HC group, the
DLB
group has severely impaired small-world network. Compared to those of the HC group, the clustering coefficients of the
DLB
group were higher and characteristic path lengths were longer, and in terms of global efficiencies, those of the
DLB
group was also lower. Moreover, four significantly altered regions were observed in the
DLB
group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (
OLF
.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). Amongst them, in the
DLB
group, betweenness centrality became strong in
OLF
.R, HIP.R, and FFG.L, whereas betweenness centrality became weaker in IFG.R. Finally, IFGoperc.R was selected as a seed and a voxel-wise correlation analysis was performed. Compared to the HC group, the
DLB
group showed several regions of strengthened connection with IFGoperc.R; these regions were located in the prefrontal cortex and regions of weakened connection were located in the occipital cortex. The results of this paper may help physicians to better understand and characterize
DLB
patients.
...
PMID:Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control. 2985 20
