Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0752347 (
Dementia with Lewy bodies
)
1,653
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Dementia with Lewy bodies
(
DLB
) is commonly associated with
excessive daytime somnolence
(
EDS
). Modafinil is a wakefulness-promoting agent that is considered to have limited interaction with the dopaminergic system. As individuals with
DLB
are predisposed to psychotic symptoms that might be exacerbated by dopaminergic stimulation, modafinil is considered to be an attractive option for the treatment of
EDS
in
DLB
. We describe 2 cases in which administration of modafinil exacerbated agitation and hallucinations in
DLB
, and we also review data that may explain the mechanisms underlying this effect. In both cases, psychotic symptoms emerged concomitantly with modafinil administration and remitted following its discontinuation. Although definitive data regarding the benefits and adverse effects of modafinil for the treatment of
EDS
in
DLB
await controlled prospective randomized studies, our observations warrant caution regarding its use in this context.
...
PMID:Agitation and psychosis associated with dementia with lewy bodies exacerbated by modafinil use. 2289 57
