Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0752347 (Dementia with Lewy bodies)
 1,653 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diffuse Lewy body disease has not been yet described in France, although some authors, essentially Japanese ones reported cases of this disease. A man began at age 56 to be very apathetic with memory disturbances. Later, he developed aphasia, stereotypies, and mild parkinsonian rigidity. He died in cachexia, three years after the onset of the disease. Post-mortem examination showed diffuse senile plaques and tangles in the cortex. But there was also a striking widening of Lewy bodies, in the pons and in the frontal, temporal and cingular cortex. These Lewy bodies were located in the 5th cortical layer, and their immature and irregular shape made them difficult to identify. The authors discuss the role of each lesions on the clinical disturbances, in regard to other described cases.
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PMID:[Dementia in diffuse cortical Lewy body disease]. 830 22

Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had neurodegenerative diseases and 1718 psychiatric disorders. After 2-9 years of follow up, 488 patients were labelled as PD, 415 as Alzheimer Disease, 162 as DLB, 48 as Progressive Supranuclear Palsy, 48 as Multiple System Atrophy and 49 as Fronto-Temporal Dementia. The frequency of SFMD (DSM-IV-TR criteria) was determined in each diagnostic category by direct observation of SFMD symptoms, psychiatric interviews, SCL 90Rss, collection of previous general practitioners and hospital charts. The frequency of SFMD was considerably higher in DLB (29 patients, 18%) and PD (37 patients, 7.5%) than in any other group (0-2%). The frequency of SFMD in psychiatric patients was 2%. SFMD in PD and DLB were characterised by motor and non-motor patterns and were often accompanied by catatonic signs consisting of posturing stereotypies and negativism (55%). SFMD symptoms preceded PD motor signs by 6 months-5 years in 92% of the 29 DLB and 37 PD patients and in 70% SFMD were recurrent at follow-up. In 93% of these patients, hypochondria was a preceding or concomitant background.
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PMID:Updates on Somatoform Disorders (SFMD) in Parkinson's Disease and Dementia with Lewy Bodies and discussion of phenomenology. 2181 40