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Pivot Concepts:
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Target Concepts:
Gene/Protein
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Query: UMLS:C0751781 (
NOD
)
6,696
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ataxic
mutant mice can be used to represent models of cerebellar degenerative disorders. They serve for investigation of cerebellar function, pathogenesis of degenerative processes as well as of therapeutic approaches. Lurcher, Hot-foot, Purkinje cell degeneration, Nervous, Staggerer, Weaver, Reeler, and Scrambler mouse models and mouse models of SCA1, SCA2, SCA3, SCA6, SCA7, SCA23,
DRPLA
, Niemann-Pick disease and Friedreich ataxia are reviewed with special regard to cerebellar pathology, pathogenesis, functional changes and possible therapeutic influences, if any. Finally, benefits and limitations of mouse models are discussed.
...
PMID:From mice to men: lessons from mutant ataxic mice. 2633 Oct 28
