Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0751651 (mitochondrial disease)
 1,844 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 186
ATP 141
tRNA 122
Sep 117
cytochrome c oxidase 99
MELAS 74
MRI 61
POLG 49
She 38
MERRF 35
NADH 28
DNA polymerase gamma 28
COX 28
frataxin 27
axonal 25
ATP synthase 21
X-linked 20
OXPHOS 20
ROS 19
LHON 17
insulin 17
cytochrome 17
CSF 16
citrate synthase 16
DNA polymerase 16
SURF1 15
NAD 15
ND4 14
ubiquinone 14
ND6 13
Barth syndrome 13
pyruvate dehydrogenase 13
cytochrome c 12
ADP 12
cytochrome b 12
creatine kinase 11
ND1 11
tafazzin 10
Cytochrome c 10
complex I) 10
pyruvate dehydrogenase complex 10
GAA 10
helicase 9
Dictyostelium 9
mTOR 9
Polymerase 9
osteosarcoma 9
MRS 9
PGC 8
catalase 8
oxidoreductase 8
GDF15 8
ND5 8
C10orf2 8
AMP-activated protein kinase 8
Pol 7
pol 7
mitochondrial transcription factor A 7
RRM2B 7
AMPK 7
TFAM 7
ND3 7
NARP 7
FRDA 7
superoxide dismutase 7
ATPase 7
TL1A 7
SDHB 7
SUCLA2 6
Fibroblast growth factor 21 6
ATP6 6
threonine 6
glutathione peroxidase 6
OPA1 6
NADH dehydrogenase 6
SCO2 6
EARS2 6
mitochondrial ATPase 6
PINK1 6
MnSOD 6
BCS1L 6
EPI 6
urocortin 6
aconitase 6
methyltransferase 6
TAZ 5
complex I assembly factor 5
MT-ND5 5
fused 5
PDHA1 5
FBXL4 5
PPAR 5
MTND1 5
antioxidant enzyme 5
SDH 5
TOM 5
MT-ND4 5
X-chromosome 5
GluRS 5
Frataxin 5
platelet-derived 5
PolB 4
transferrin 4
ubiquitin 4
NADH-ubiquinone oxidoreductase 4
DARS2 4
COQ4 4
AED 4
NDUFS4 4
WFS1 4
YARS2 4
ACAD9 4
Q10 4
DDP 4
P43 4
peroxisome proliferator-activated receptor 4
ADCK3 4
NDUFA1 4
thymidine phosphorylase 4
GSH 4
NDUFAF1 4
MTATP6 4
ATPase 6 4
Parkin 4
cytochrome aa3 4
SDS 4
manganese superoxide dismutase 4
PEO 4
flavoprotein 4
nuclear receptor 4
Bcl-2 4
erythroid 4
p53 4
proteasome 4
ANT 4
polypeptide 4
desmin 4
TMEM70 4
COQ9 4
transcobalamin II 4
Peroxisome proliferator-activated receptor 3
NDUFV1 3
dynamin-related protein 1 3
NDUFS3 3
PGL 3
UTR 3
SUCLG1 3
MTND3 3
outer mitochondrial membrane 3
GTP 3
chronic renal failure 3
NDUFB8 3
SWI 3
MFN2 3
NDUFS2 3
Met 3
TK2 3
endoplasmic reticulum 3
gut 3
ETHE1 3
more...
Disease
mitochondrial disease 1844
lactic acidosis 206
Leigh syndrome 149
encephalopathy 149
stroke 147
myopathy 131
epilepsy 117
mitochondrial myopathy 109
Leber's hereditary optic neuropathy 109
cardiomyopathy 101
diabetes 101
MELAS 88
MELAS 74
mitochondrial encephalomyopathy 72
deafness 68
neuropathy 67
Kearns-Sayre syndrome 56
prolapse 47
developmental delay 46
hypertrophic cardiomyopathy 41
cancer 36
sensorineural hearing loss 36
MERRF 35
Alpers 32
heart failure 31
optic atrophy 30
myoclonus epilepsy 30
Friedreich's ataxia 28
Parkinson's disease 27
failure to thrive 24
anemia 22
peripheral neuropathy 22
status epilepticus 22
mental retardation 20
migraine 20
mental retardation 20
Chronic progressive external ophthalmoplegia 20
retinitis pigmentosa 20
blindness 20
dilated cardiomyopathy 20
leukoencephalopathy 20
depression 18
Alzheimer's disease 17
renal disease 17
neurological disease 17
autism 17
hypoglycemia 16
retinopathy 16
polyneuropathy 14
renal failure 14
Fanconi 14
respiratory failure 14
Complex I deficiency 14
dementia 14
heart block 14
liver disease 14
cognitive impairment 13
Barth syndrome 13
fits 12
muscular atrophy 12
multiple sclerosis 12
dysphagia 12
sideroblastic anemia 11
ischemia 11
heart disease 10
brain atrophy 10
Pearson's syndrome 10
hypertension 10
leukodystrophy 10
nystagmus 9
obesity 9
osteosarcoma 9
movement disorder 9
sepsis 9
preeclampsia 9
MRS 9
parkinsonism 9
hypothyroidism 9
cataract 9
sepsis 9
HIV 9
Fanconi syndrome 9
dysplasia 9
enzyme deficiency 9
congestive heart failure 9
neutropenia 8
proteinuria 8
vascular disease 8
wasting 8
IBM 8
amyotrophic lateral sclerosis 8
genetic disorder 8
fatty liver 8
rare disease 7
Fabry 7
Charcot-Marie-Tooth disease 7
hyperlipidemia 7
virus infection 7
metabolic disorder 7
type 2 diabetes 7
infertility 7
tumor 7
Syndrome 7
glomerulosclerosis 7
immunodeficiency 6
Autism spectrum disorder 6
neuromuscular disorder 6
lipomatosis 6
malignant hyperthermia 6
malnutrition 6
motor neuron disease 6
myocardial infarction 6
pancreatitis 6
EPI 6
OPA1 6
Wolfram syndrome 5
Huntington's disease 5
nephrotic syndrome 5
bipolar disorder 5
vasculitis 5
DDP 5
cold 5
acute pancreatitis 5
ventricular hypertrophy 5
myositis 5
psychosis 5
iron overload 5
AIDS 5
atrioventricular block 5
cholestasis 5
spastic paraplegia 5
myasthenia gravis 5
FRDA 5
schizophrenia 5
polymyositis 4
adrenal insufficiency 4
moyamoya 4
diplopia 4
hallucinations 4
prematurity 4
LCA 4
Hypertrophic cardiomyopathy 4
CNS diseases 4
Rett syndrome 4
AMD 4
glaucoma 4
male infertility 4
hypoparathyroidism 4
gestational diabetes mellitus 4
major depressive disorder 4
hyperthyroidism 4
PDH deficiency 4
strabismus 4
methylmalonic acidemia 4
Wilson's disease 4
encephalitis 4
DM1 4
scotoma 4
thrombocytopenia 4
SDS 4
more...
Symptom
seizures 119
ophthalmoplegia 113
weakness 76
ataxia 72
hypotonia 50
fatigue 33
anesthesia 21
cerebellar ataxia 19
myoclonus 18
dysarthria 18
dystonia 17
headache 16
diarrhea 11
myalgia 10
vomiting 9
spasticity 9
pain 8
tremor 8
hepatomegaly 7
sleepiness 6
lethargy 6
dyspnea 5
muscle cramps 5
hyperoxia 5
starvation 4
abdominal pain 4
analgesia 3
cachexia 3
collapse 3
paraparesis 3
constipation 3
nausea 2
Sensory ataxia 2
Ataxic 2
syncope 2
hemiplegia 2
respiratory distress 2
exhaustion 2
chorea 2
nausea and vomiting 2
paresis 2
paresthesia 2
blurred vision 2
tonic-clonic seizure 2
incoordination 1
dizziness 1
DNA marker 1
dysesthesia 1
ENT 1
overweight 1
partial seizure 1
hepatosplenomegaly 1
clumsiness 1
pallor 1
polyuria 1
hypersomnia 1
fasciculation 1
hyperemesis 1
External ophthalmoplegia 1
spasm 1
hypothermia 1
bradykinesia 1
thinning 1
asthenia 1
chest pain 1
hip pain 1
polydipsia 1
benign congenital hypotonia 1
Exercise intolerance 1
Postoperative pain 1
neck pain 1
neurological disability 1
anorexia 1
ataxic gait 1
impaired motor coordination 1
hypocapnia 1
numbness 1
muscle stiffness 1
Ophthalmoparesis 1
hypertonia 1
erythema 1
Cold intolerance 1
cough 1
snoring 1
hypercapnia 1
ketonuria 1
abnormal gait 1
Drug
NADH 28
ROS 19
CSF 16
lysine 10
EPI 6
ascorbate 5
Cardiovasc 4
Idebenone 4
Parkin 4
Parkin 4
Alliance 3
vitamin E 3
Riboflavin 3
Mutagen 3
Glutathione 3
FAD 2
Nephron 2
Gel 2
ISP 2
niacin 2
Leaf 2
Vitamin E 2
AZT 2
Nephron 2
AZT 2
citric acid 2
Asn 2
OTC 1
BLM 1
Fluorescein 1
Spectrum 1
MDS 1
DMAP 1
IL-2 1
Clofibrate 1
Caspofungin 1
TAT 1
ICI 1
ENT 1
Kainic acid 1
PCP 1
Sodium valproate 1
Apomorphine 1
caffeine 1
Portal 1
ROC 1
MRC 1
Fluorescein 1
OTC 1
Rosiglitazone 1
Propofol 1
RFP 1
Spectrum 1
EPA 1
Enzyme
complex I 176
cytochrome oxidase 70
succinate dehydrogenase 51
ATP synthase 24
pyruvate dehydrogenase 23
DNA polymerase 22
ATPase 18
citrate synthase 16
AMP-activated protein kinase 15
pyruvate dehydrogenase 13
pyruvate dehydrogenase 13
creatine kinase 11
superoxide dismutase 10
diaphorase 10
NADH dehydrogenase 9
catalase 8
AMPK 7
AMPK 7
glutathione peroxidase 6
aconitase 6
RNase P 5
acyl-CoA dehydrogenase 5
protein kinase 5
mitogen-activated protein kinase 5
thymidine phosphorylase 4
proteasome 4
NQO1 3
alanine aminotransferase 3
luciferase 3
acyl-CoA dehydrogenase 3
topoisomerase 3
reverse transcriptase 3
topoisomerase 3
aspartate aminotransferase 3
ornithine transcarbamylase 3
CPR 3
chaperonin 2
endonuclease 2
succinic dehydrogenase 2
ERK 2
aspartyl-tRNA synthetase 2
phosphoinositide 3-kinase 2
PDK1 2
xanthine oxidase 2
ribonucleotide reductase 2
lactate dehydrogenase 2
ribonucleotide reductase 2
glutathione S-transferase 2
MEK 1
rhomboid protease 1
ferrochelatase 1
TMT 1
acylglycerol kinase 1
ECH 1
TAT 1
glutaryl-CoA dehydrogenase 1
ACE 1
ribonuclease 1
SCS 1
succinyl-CoA synthetase 1
enolase 1
glyceraldehyde-3-phosphate dehydrogenase 1
lipase 1
glutamine synthetase 1
PHD 1
purine nucleoside phosphorylase 1
ribonuclease 1
nucleotidase 1
MDH 1
MMP 1
PNGase F 1
phosphofructokinase 1
DNase 1
deoxyguanosine kinase 1
PRPP synthetase 1
tRNA isopentenyltransferase 1
PARP 1
RNase 1
tryptophanyl-tRNA synthetase 1
TdT 1
PDH 1
21-hydroxylase 1
glycerol-3-phosphate dehydrogenase 1
MDH 1
RNase 1
alkaline phosphatase 1
pepsin 1
alpha-ketoglutarate dehydrogenase 1
MIP 1
phenylalanyl-tRNA synthetase 1
MPP 1
GMP reductase 1
histidyl-tRNA synthetase 1
transcriptase 1
renin 1
sulfur dioxygenase 1
adenosine deaminase 1
tRNase Z 1
adenosine deaminase 1
UDP-glucuronosyltransferase 1
IscS 1
thymidine kinase 1
PCP 1
sulfhydryl oxidase 1
glycerol kinase 1
branching enzyme 1
adenylosuccinate lyase 1
transglutaminase 1
glycerate kinase 1
LasR 1
RNA polymerase 1
phosphatidylserine decarboxylase 1
NADPH-diaphorase 1
pyruvate carboxylase 1
calcineurin 1
gamma-glutamyl transpeptidase 1
tyrosine hydroxylase 1
malate dehydrogenase 1
biotinidase 1
glycerol-3-phosphate dehydrogenase 1
alanyl-tRNA synthetase 1
Compound
DNA 644
ATP 141
oxygen 135
Dec 117
Clin 71
leucine 46
glucose 36
iron 32
coenzyme Q10 32
COX 28
NADH 28
lysine 27
calcium 22
ubiquinone 22
His 21
alanine 21
ADP 18
sodium 18
NAD 18
CoQ 17
arginine 16
Coenzyme Q10 16
phosphate 16
ammonium 15
NAD 15
Cardiol 14
water 13
phosphocreatine 12
ADP 12
ADP 12
serine 12
phosphorus 11
galactose 10
Cytochrome c 10
urea 10
nicotinamide 10
nitric oxide 10
creatinine 9
Phe 9
copper 9
methionine 8
hydrogen 8
CoA 8
cysteine 8
threonine 8
Lactate 7
uridine 7
glutamate 7
tyrosine 6
H2O2 5
GSH 5
bromide 5
L-carnitine 5
GSH 5
potassium 4
SDS 4
pyrimidine 4
zinc 4
CO2 4
pyrimidine 4
Rapamycin 4
TCA 4
manganese 4
proline 4
isoleucine 3
isoleucine 3
folinic acid 3
aspartic acid 3
N-acetylaspartate 3
Riboflavin 3
AICAR 3
tungsten 3
FAD 3
NADPH 3
A 3 3
N-acetylcysteine 3
NADPH 3
pentose 3
FMN 3
aspartic acid 3
pentose 3
H2S 3
sulfate 3
CIT 3
Guo 3
2-oxoglutarate 3
ubiquinol 3
valine 3
aspartic acid 3
Neuronal 3
Ile 3
ammonia 3
pentose 3
aspartic acid 3
salt 3
GTP 3
NADP 3
Asp 3
AICAR 3
glutamine 3
GSSG 3
glutamic acid 3
Guo 3
pentose 3
AMP 2
COI 2
asparagine 2
MTT 2
aluminum 2
Retinal 2
nicotinic acid 2
DDP 2
adenosylmethionine 2
GABA 2
propionic acid 2
cadmium 2
GABA 2
AZT 2
Rotenone 2
Isoproterenol 2
nicotinic acid 2
acetyl-CoA 2
Vitamin E 2
pyridine 2
cyanide 2
nicotinic acid 2
DSM 2
Cereb 2
propionic acid 2
nicotinic acid 2
nitrogen 2
Wellcome 2
Taurine 2
CIT 1
PCP 1
Gentamicin 1
CAP 1
MPP 1
CoQ9 1
reduced riboflavin 1
CCP 1
ornithine 1
decanoic acid 1
tryptophan 1
carbonate 1
naphthoquinone 1
acetic acid 1
DES 1
DAMP 1
Ferricyanide 1
Testosterone 1
naphthoquinone 1
caffeine 1
3-methylcrotonyl-CoA 1
Argentine 1
Estrogen 1
dGMP 1
POP 1
Enalapril 1
Epigallocatechin 1
more...