Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0751295 (
memory loss
)
3,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Quinone reductase 2
(
QR2
), a detoxifying cytosolic flavoenzyme, is thought to play an important role in the acquisition and
loss of memory
. We determined the amount of
QR2
in the hippocampus, amygdala, and superior frontal gyrus of Alzheimer's disease (AD) patients with dementia by using western blot analysis. The level of
QR2
was significantly higher in the hippocampus of AD patients than in that of the control subjects. The relation between
QR2
and AD has not yet been determined; however, our results suggest that the increase in hippocampal
QR2
might be a cause of AD or might promote the progression of AD by causing an increase in the toxic quinone levels and consequent loss of cognitive function.
...
PMID:Increased hippocampal quinone reductase 2 in Alzheimer's disease. 2180 22
