Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0751295 (memory loss)
 3,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hallucinogens are the chemicals which in nontoxic doses produce changes in perception, mental confusion, memory loss, or disorientation for person, place and time, with organic brain reactions. Mescaline and LSD are historically the most interesting hallucinogens. Today the cannabis is very important, socially. Traditional hallucinogens survive everywhere in the world. A dramatic increase in use of cartoons in drug education and prevention programs prove great damages: in comics and films often have stimulated the appetite for drug experimentation (seduction of innocent, R. K. Siegel). Cartoons and comics are instruments for correcting perceptions and behaviour of youth and youthful drug abusers. As the hallucinogens.
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PMID:[The ethnopharmacology of hallucinogens: from "primitive rites" to their "presence" on TV. Proposals for the year 2000]. 926 6

Recently, flunitrazepam (Rohypnol) has become an increasingly popular drug of abuse among young adults, who take it for its euphoric effects. In other cases, the drug has been used by rapists for its sedative and hypnotic effects that can induce a catatonialike trance and memory loss in potential victims; as a result, it has been nicknamed the "date-rape drug". For these reasons, the Drug Enforcement Administration recently considered adding the drug (a.k.a. "Roofies") to the same category as heroin and LSD. A selective and sensitive technique has been developed for extracting, detecting, and identifying flunitrazepam and its two major metabolites (7-aminoflunitrazepam and N-desmethylflunitrazepam) in human urine. Using a solid-phase extraction cartridge containing a "mixed-mode" bonded silica gel (Bond Elut Certify), flunitrazepam and its metabolites were selectively isolated from other urine components and quantitated and identified by gas chromatography-tandem mass spectrometry with a benchtop ion mass spectrometer. The extraction method is rapid, reproducible, and precise, and it has a broad linear working range. The overall extraction efficiency was found to be more than 90% for the parent drug as well as the two major metabolites.
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PMID:Rapid method for the solid-phase extraction and GC-MS analysis of flunitrazepam and its major metabolites in urine. 1065 68