Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0751295 (
memory loss
)
3,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by
memory loss
and cognitive dysfunction.
Aquaporin-4
(
AQP4
), which is primarily expressed in astrocytes, is the major water channel expressed in the central nervous system (CNS). This protein plays an important role in water and ion homeostasis in the normal brain and in various brain pathological conditions. Emerging evidence suggests that
AQP4
deficiency impairs learning and memory and that this may be related to the expression of glutamate transporter-1 (GLT-1). Moreover, the colocalization of
AQP4
and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the
AQP4
/GLT-1 complex may have on AD. Research on the functional interaction of
AQP4
and GLT-1 has been demonstrated to be of great significance in the study of AD. Here, we review the interaction of
AQP4
and GLT-1 in astrocytes, which might play a pivotal role in the regulation of distinct cellular responses that involve neuroprotection against AD. The association of
AQP4
and GLT-1 could greatly supplement previous research regarding neuroprotection against AD.
...
PMID:The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer's Disease. 2705 65
