Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0751295 (
memory loss
)
3,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excitatory pyramidal neurons in the entorhinal cortical layer II region (ECII
PN
) form functional excitatory synapses with CA1 parvalbumin inhibitory neurons (CA1
PV
) and undergo selective degeneration in the early stages of Alzheimer's disease (AD). Here, we show that
death-associated protein kinase 1
(
DAPK1
) is selectively activated in ECII
PN
of AD mice. Inhibition of
DAPK1
by deleting a catalytic domain or a death domain of
DAPK1
rescues the ECII
PN
-CA1
PV
synaptic loss and improves spatial learning and memory in AD mice. This study demonstrates that activation of
DAPK1
in ECII
PN
contributes to a
memory loss
in AD and hence warrants a promising target for the treatment of AD.
...
PMID:Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1. 2779 39
