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Query: UMLS:C0751295 (memory loss)
 3,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Elderly patients often manifest a variety of symptoms (e.g., depression, memory loss, irritability, hostility), categorized as "senility" or "senile dementia," which are difficult to treat and represent a major therapeutic challenge to the geriatrician. This investigation was designed to assess, under double-blind conditions, a drug often prescribed for these symptoms--cyclandelate. In a 16-week study, 58 elderly patients were randomly assigned to two groups and received either 1600 mg of cyclandelate daily or identical-appearing placebo capsules. Initially, the every four weeks thereafter, the patients were examined for changes in vital signs and for adverse reactions, also, the Sandoz Clinical Assessment-Geriatric (SCAG) Scale and the Nurses Observation Scale Inpatient Evaluation (NOSIE) were completed. At the final evaluation, a physician's global rating was obtained. Our data suggest that cyclandelate is a safe and moderately effective treatment for certain symptoms of senescence in carefully selected patients.
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PMID:Cyclandelate in the treatment of senility: a controlled study. 35 21

In the elderly, physical and mental concemitants of chronic and explainable ill health are often masked by the diagnosis of senility. The presentation of major illness in the elderly is commonly nonspecific, and a full physical examination and tests with special attention to infections and to the signs of endocrine and metabolic disorders should be carried out. Symptoms such as confusion and memory loss, hostile or difficult behavior, and dementia point to different probable causes, and the physician should carefully search for the underlying pathology.
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PMID:The myth of senility. Diagnosing nonspecific major illness in the elderly. 41 27

A case of pure memory loss occurred suddenly following inhalation anesthesia. Examination seven years after the onset of amnesia disclosed a profound and selective impairment of recent memory without concomitant deterioration of other higher functions or evidence of other neurologic abnormalities. Pneumoencephalotomography focused on the temporal horns showed severe atrophic changes confined to both hippocampi. This finding provides a radiologic counterpart of previously reported surgical and pathological observations of bilateral hippocampal lesions in cases with relatively pure loss of memory.
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PMID:Pure memory loss with hippocampal lesions: a pneumoencephalographic study. 42 Jun 10

Transient global amnesia is a clinical syndrome characterized by sudden onset of short-term memory loss followed by retrograde amnesia in an otherwise healthy subject. During the attack, the patient remains alert and retains much of his personal identity. The patient usually becomes upset and concerned about his memory loss. This condition may be diagnosed incorrectly as hysteria, psychosis, or temporal lobe seizure, despite its unique clinical features.
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PMID:Transient global amnesia. 42 19

There is a need for rapid and convenient assessment instruments to test the aged for senile confusion due to organic brain syndrome (OBS). The Mental Status Questionnaire (MSQ) and the Face-Hand Test (FHT) have certain limitations. A valid instrument must measure short-term memory loss and recognition. Sixty-two patients were examined in 17 different trials of the Stimulus Recognition Test (SRT), which involves 10 items. Each item classified the patients according to staff ratings (P less than .001), MSQ MSQ scores (P less than .005), and FHT scores (P less than .005). The composite MSQ score on a scale of 0--10 also served to separate the patients according to staff ratings (P less than .005). The SRT scores correlated .81 to .67 with the MSQ and FHT scores. The SRT does not show the same false positive patterns as the MSQ and FHT. For that reason, it constitutes a useful diagnostic supplement. Suggestions for further research are made.
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PMID:Senile confusion: assessment with a new stimulus recognition test. 42 32

The authors present a 60-year-old patient undergoing periodic hemodialysis who, 3 years after beginning the treatment, developed a clinical picture consisting of disturbances of language, motor dispraxia, loss of memory and concentration, irritability, great change of personality, myoclonias and asterixis. This led progressively to a total loss of motor coordination, including speech. He died 5 months later in a state of dementia, psychosis and incontinence of sphincters. The symptomatology increased after hemodialysis sessions. The normal analytical studies carried out in these cases (electrocardiogram, electromyography, complete roentgenologic study) and also Zn, Cu, and ceruloplasmin measurements were normal. The electroencephalogram showed only a slow tracing with delta waves. Various etiopathogenic possibilities are commented on, as for example alterations in the dialysis water, the use of detergents in cleaning the artificial kidney, a syndrome of imbalance, a decrease in the body potassium and poisoning caused by certain metals such as tin, zinc and aluminium or by drugs which contain benzodiazepine derivatives. The authors conclude that the picture corresponds to a metabolic encephalopathy.
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PMID:[Dementia and hemodialysis (author's transl)]. 43 Nov 64

The appearance of the amnestic episode is discussed by presentation of 4 own cases and by means of literature. The amnestic episode is a mental disorder, which exclusively affects short-term memory with a sudden onset and a duration of some hours, seldom up to several days, and often it is connected with a retrograde amnesia. The latter disappears in all cases, but there remains a permanent lack of memory for the time of the episode. Recidivism is rare. Internal, neurological and neurophysiological findings during and after the amnestic episode regularly are normal, at least certainly without characteristic findings. The main age of manifestation lies between the 40th and 70th year of life, there is no priority between women and men. Probably a disturbance of blood flow in the supplying area of the basilaric arteria is responsible, though the proof is still missing.
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PMID:[Amnestic episode (transient global amnesia) (author's transl)]. 44 Jan 80

A word recognition task was designed to determine the stage in memory affected by a single 10-mg intravenous injection of diazepam and the duration of the effect. Injection in three experimental subjects produced an anterograde amnesia for the 14 to 24-minute period immediately after injection. Memory loss resulted from impaired storage, the stage during which information is entered into memory. Retention and retrieval stages of memory were unaffected. This temporary amnesia may result from increased inhibition in the hippocampal system produced by diazepam, which shares many properties with the inhibitory neurotransmitter gamma-aminobutyric acid.
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PMID:The pattern of memory loss resulting from intravenously administered diazepam. 44 98

Memory loss is often a subjective symptom rather than an objective one. Complaints of poor memory appear to be related to stereotypes of aging and to the presence of depression, rather than to chronic brain disease. Reassuring an elderly person that occasional forgetfulness does not indicate senility, and improving morale in those who are depressed, effectively reduce exaggerated memory concerns.
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PMID:Helping an aging patient to cope with memory problems. 44 73

Six-, 8-, 10-, and 12-year-old children (10 boys and 10 girls) reconstructed two visual patterns from immediate memory, while other 5- and 6-year-old children (10 boys and 10 girls) reconstructed the identical patterns by direct copying. Patterns were simple and composed entirely of circles or squares as component items. Four results were emphasized: (a) Numerous errors mady by the copying groups led to the conclusion that memory loss is often overestimated in young children. Since an independent estimate of perceptual encoding errors is rarely carried out, encoding mistakes are often included among forgetting errors. (b) One pattern was both copied and remembered more poorly than the other in accord with a Piagetian interpretation of a conceptual conflict inherent in the pattern design between spatial and numerical correspondence of component pattern items. (c) A memory strategy emphasizing configuration preservation was suggested for the 6-year-olds who made slightly fewer memory than copying errors for two configural scoring categories. (d) Performance in an unrelated planning-for-memory task significantly differentiated between better and worse performers on the visual pattern memory task.
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PMID:Memorizing and copying visual patterns: a Piagetian interpretation. 46 4


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