Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0751295 (
memory loss
)
3,619
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Prolyl oligopeptidase
(
POP
) is a ubiquitous post-proline cleaving enzyme that is highly expressed in brain. Current knowledge about the biochemical features of
POP
and the pharmacological action of its specific inhibitors has indicated that
POP
participates in several aspects of the central nervous system (CNS), including learning, memory and mood. Furthermore, a role has been suggested for
POP
in pathological processes such as eating and mood disorders, hypertension and cell-cycle disturbances, in addition to its proposed connection with the neurodegenerative processes which occur in Alzheimer's, Huntington's and Parkinson's diseases. The milestones responsible for the accelerated development of
POP
inhibitors include the discovery that these compounds reverse
memory loss
in animal models of drug- or lesion-induced amnesia and the observation that the expression of
POP
correlates with age. Today, several
POP
inhibitors have already been evaluated in preclinical trials as potential drugs for the treatment of natural memory deficits that occur with aging or the pathological
memory loss
characteristic of Alzheimer's disease. Thus, the results that are emerging from basic research on
POP
function will facilitate the fine-tuning of more efficient drugs to target this protease.
...
PMID:Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders. 1787 57
Inhibitors of
prolyl oligopeptidase
have been reported to be neuroprotective, especially in
memory loss
caused by lesion or disease. This enzyme has also been implicated in neurodegeneration. Although it was initially thought that
prolyl oligopeptidase
functioned to directly control of neuropeptide levels, emerging evidence points out in part that this peptidase modulates peptides which in turn regulate inflammatory responses. Here we review the recent literature which indicates a direct involvement of
prolyl oligopeptidase
in several inflammatory diseases. Neuroinflammation generates neurotoxins with a relevant role in neurodegenerative diseases, and it is within this toxin generation where
prolyl oligopeptidase
might have a role.
...
PMID:Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research. 2122 23
