Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0751295 (memory loss)
 3,619 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 35-year old man was presented with organic psychosyndrome. Anamnestic reports informed about changes in his behaviour like loss of interest, reduced concentration and short-term-memory loss within the last 2 years. The practicing psychiatrist diagnosed a depressive syndrome in conjunction with a borderline syndrome and administered antidepressive and neuroleptic therapy. Specific serologic tests were not done. Neurologically, there was a picture of influent and slurred speech, and ataxic gait. Muscle tonus was normal, muscle reflexes were of the same diminished intensity on both sides. The psychic status revealed a person mostly oriented in time, location and situation but with severe disorders of recognition, concentration, and memory. Laboratory diagnosis proved the suspected diagnosis of neurosyphilis. Additionally, there were antibodies to Borrelia burgdorferi (Bb) in serum and CSF and a positive CSF/serum index of 9.0 (threshold: 1.9). The neuroradiologic examination (CCT, NMR, SPECT) showed an intense, diffuse, frontotemporal atrophy of the cortex. By NMR, massive gliosis was found in both hippocampi. Angiographically, an aneurysma (1 cm in diameter) of the medial cerebral artery was demonstrated. Specific treatment was performed with Na penicillin (5 Mio. i.v./4 h over 21 days). No remission could be achieved.
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PMID:[Neurosyphilis. A case report and review of the literature on differential neuroborreliosis diagnosis]. 761 Jun 72

We reported a 32-year-old man with general paresis. He showed slowly progressive bradykinesia and recent memory loss. Argyll Robertson pupils were not present. Muscle strength and sensations were normal except for slight vibratory disturbance. Tendon reflexes were slightly exaggerated. MMSE, HDS-R and WAIS-R scores showed the intellectual impairment. His laboratory investigations revealed elevated both TPHA and FTA-ABS titers in the serum and the CSF. The CSF contained leukocytosis (25/mm3) and protein 80 mg/dl. Cranial CT and MRI demonstrated diffuse cortical atrophy. SPECT revealed marked reduction of the blood flow in bilateral cerebral hemisphere. Cerebral angiography revealed moderate stenosis of the major vessels. The diagnosis of neurosyphilis (general paresis) was made and the treatment of intravenous benzyl penicillin potassium 24 million units per day was started. After 6 weeks of the treatment, the clinical signs (includes MMSE, HDS-R and WAIS-R scores) and the findings of SPECT and cerebral angiography showed improvement. Although the cell count and protein in the CSF became decreased, the titers of TPHA and FTA-ABS in the serum and the CSF were not decreased. Neurosyphilis should always be considered in a etiologically unknown case with bradykinesia and dementia.
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PMID:[Therapeutic case of general paresis manifested by bradykinesia and recent memory loss]. 1061 61

Authors report a case of a 35-year-old male with right-sided mild paresis, incontinence, dysexecutive syndrome, short-term memory loss and behavioral changes. Bilateral cerebral infarcts in the region of the caudate nuclei and the adjacent white matter were proved by brain MRI and multiple stenoses of the branches of Willis-circle were confirmed by MR angiography. Elevated protein level and pleocytosis were found in the cerebrospinal fluid with intrathecal IgG synthesis. Serum rapid plasma reagin, Treponema pallidum Particle Agglutination test, Treponema pallidum ELISA, liquor Venereal Disease Research Laboratory tests were positive. Meningovascular neurosyphilis was diagnosed. 24M U/day intravenous penicillin-G treatment was given for 14 days. The patient has vascular dementia due to the bilateral strategic infarcts disconnecting the prefrontal circuits; his symptoms are similar to general paresis. Laboratory and radiologic improvement was observed. Still, the patient have severe residual cognitive decline.
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PMID:[Meningovascular neurosyphilis as the cause of ischemic cerebrovascular disease in a young man]. 2149 67

Acute confusion and memory loss associated with asymmetrical mesiotemporal hyperintensity on T2-weighted MRI are characteristic of herpes encephalitis. The authors report the case of a patient with these symptoms and MRI presentation who had neurosyphilis. Recently clinical and imaging patterns usually associated with herpes simplex encephalitis have been seen in patients with neurosyphilis. Because syphilis is "The Great Pretender" not only clinically but also in imaging and because its numbers are rising, it must be sought as a differential diagnosis.
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PMID:Neurosyphilis versus Herpes Encephalitis in a Patient with Confusion, Memory Loss, and T2-Weighted Mesiotemporal Hyperintensity. 2256 86

The incidence of neurosyphilis has declined dramatically because of the availability of penicillin. However, in recent years there has been an increase in the occurence of neurosyphilis. General paresis, a form of parenchymatous neurosyphilis, causes dementia. Some of the symptoms include loss of memory, poor understanding and judgment, and behavioral changes. It is important to distinguish general paresis from neurodegenerative disorders such as Alzheimer's disease, because with precise diagnosis and treatment, complete recovery is possible We describe epidemiological data, diagnosis and treatment of neurosyphilis as well as present our cases.
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PMID:[Neurosyphilis and Dementia]. 2705 49