Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0745411 (irregular bleeding)
 386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study aimed to evaluate the clinical and metabolic effects of a low-dose triphasic oral contraceptive containing gestodene, a new 19-nortestosterone derivative, among 42 healthy women aged 19-43 years during 6 months of treatment. Absence of any absolute or relative contraindications to hormonal contraception was the criterion for the subjects. Findings revealed that the pill exerted good cycle control and the incidence of irregular bleeding was very low. As for the coagulatory system, there was an increase in prothrombin activity and in fibrinopeptide A plasma levels, while there was a decrease in activated partial thromboplastin time. Antithrombin III activity, fibrinogen concentration and platelets count did not change during pill intake. No significant modifications in plasma total cholesterol, low density lipoprotein-cholesterol or in the subfraction high density lipoprotein 2-cholesterol (HDL2-CH) were observed. Serum triglyceride (HDL-CH and HDL3-CH) levels were significantly higher at the end of treatment. The pill did not alter fasting insulin and glucose levels or their response to an oral glucose tolerance test. Therefore, the preliminary findings suggest that the new triphasic formulation containing gestodene seems to be a safe and reliable preparation, as demonstrated by its regular cycle control, good contraceptive efficacy, and low incidence of subjective and objective side effects.
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PMID:Clinical and metabolic effects of a triphasic pill containing gestodene. 148 72

This retrospective, multicenter analysis was conducted on all adolescents admitted to three pediatric hospitals in Montreal, Quebec, Canada, over a 10-year period (1981-1991) with a primary diagnosis of dysfunctional uterine bleeding. The purpose was to assess the frequency of underlying medical disorders and their response to medical therapy. Sixty-one patient charts were identified. Newly diagnosed hematologic abnormalities were found in two patients (one with immune thrombocytopenic purpura and one with acute promyelocytic leukemia). Furthermore, all patients who were evaluated had normal factor VIII levels, partial thromboplastin times and prothrombin times. Twenty-nine percent of the patients had a past history of a significant medical problem. The mean age at presentation was 13.8 +/- 2.1 (SD) years. More than 50% of the patients had a history of irregular bleeding. Most patients (93.4%) responded to medical management. Only five (8.2%) required dilation and curettage. The history of irregular cycles, the early presentation after menarche, the infrequency of hematologic problems but high frequency of significant medical problems led us to conclude that the etiology of dysfunctional uterine bleeding in adolescence is often related to persistent immaturity of the hypothalamic-pituitary-ovarian axis. Medical therapy is highly effective in controlling such bleeding. Dilation and curettage is rarely required.
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PMID:Dysfunctional uterine bleeding in adolescents. 783 20