Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0745411 (irregular bleeding)
 386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

107 women had IUDs removed, and the IUDs were studied to determine the correlation between length of insertion and the amount of deposits on the IUD. 69 IUDs in place for 10-54 months were removed from women who reported no difficulty with them, 21 IUDs in place for 6-42 months were removed from women who had repeated irregular bleeding, and 17 IUDs in place for 5-35 months were removed during the interruption of 5-12 week pregnancies. After extraction, the IUDs were washed in deionized water and air dried before the material adhering to them was weighted. When the curve of mg material versus time is plotted, it resembles a parabola whose highest point occurs at 21 months for both the IUDs which caused excessive or irregular bleeding and those which caused no adverse symptoms. Before 21 months after insertion, the growth of deposits was slower when bleeding irregularities were present than during asymptomatic insertions. After 21 months, there appears to be no correlation between the amount of material adhering to the IUD and method complications (irregular and excessive bleeding) or method failure (pregnancy). Endometrial material is first found adhering to plastic IUDs 4 months after insertion. In metal IUDs this occurs later. Presumably metal IUDs are less irritating than plastic ones.
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PMID:[The amount of deposits adhering to the surface of IUD "Dana super" in dependence on the time of insertion (author's transl)]. 42 98