Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0745411 (
irregular bleeding
)
386
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been reported that
HCG
(human chorionic gonadotropins) found in IUD users is a sign of an implantation of fertilized ovum, and that
irregular bleeding
in the IUD users may be a sign of an early abortion. Other authors contend, however, that
HCG
levels found in IUD wearers coincide with the peak of LH (luteinizing hormone) and are therefore a sign of cross reaction rather than the actual presence of real
HCG
. This study was conducted to investigate the presence of
HCG
during the luteal phase of 21 IUD wearers (aged 22 to 39 years) with menstrual cycles ranging from 25 to 33 days. A total of 80 blood samples was collected and analyzed for levels of
HCG
B-subunit, LH, and progesterone using radioimmunoassays. 10 women did not exhibit measurable amounts of B-subunit of
HCG
. In the other 11, very small amounts of
HCG
were detected (all under 3 mIU/ml. In 1 case, level of progesterone measured (0.6 to 0.7 ng/ml) pointed to a lack of ovulation while in another case, the highest level of
HCG
(2.5 mIU/ml paralleled the peak of LH reached at 44.6 mIU/ml. The findings suggest that cross reactivity causes the presence of small amounts of
HCG
in the blood of IUD wearers.
...
PMID:Human chorionic gonadotropin in intrauterine device users. 611 29
