Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0745411 (irregular bleeding)
 386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 59-year old woman attending the gynecology clinic of the De Soysa Maternity Hospital, Colombo, Sri Lanka, complained of having a brownish vaginal discharge for four years. Initial examination to determine the cause led to a more intense examination conducted under anesthesia, dilation, and curettage. A lippes loop was found in the uterine cavity even though the subject denied practicing contraception and a large amount of yellowish granular material was evacuated. Microbiological analysis confirmed the diagnosis of actinomycosis. This is the first such case to be reported in Sri Lanka. Large doses of intravenous crystalline penicillin were given for two weeks, but symptoms remained. An abdominal hysterectomy and bilateral salpingo-oophorectomy were thus performed after which penicillin administration continued for an additional six weeks. The subject was discharged on tetracycline 500 mg qid for six weeks and was completely cured. Actinomycosis israelii is a gram positive anaerobic filamentous bacterium, a commensal of the gut. Pelvic actinomycosis was until recently considered to be rare and usually caused by a ruptured appendix when it did occur. The organism has recently been associated with IUDs, especially after two years of use, following a route of infection from the anus across the perineum and upwards through the vagina and cervix via the string of the IUD. The combination of a foreign body causing trauma and the adjacent heavy anaerobic flora of the vagina provide ideal conditions for the organism. Clinical manifestations of pelvic actinomycosis are local endometrial infection giving rise to chronic pain, an offensive vaginal discharge, and irregular bleeding per vaginam.
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PMID:Actinomycosis of the uterus. 847 89

This study included 125 women with specific complaints following tubal ligation. In most instances the ligations had been done 7 years previously, mostly for multiparity. 92% had been ligated by the abdominal route 88.8% had symptoms including menstrual irregularities, chronic pain, obesity, psychoses, intermittent acute retention of urine, ventral hernia, and 2 cases of sterilization failure. Average age at time of tubectomy had been 31 years; average parity, 3-4. There was a shift towards right in mean maturation index of cervical cells soon after sterilization. This shift then decreased for a year, then gradually rose, stabilizing at 12 years. Amenorrhea was present in 5 cases with high mean maturation levels. 17 cases of oligomenorrhea all showed ahigh estrogenic activtiy. Of 27 cases of menorrhagia endometrial biopsies were taken in 13. 12 showed the proliferative phase and 1 the secretory phase. These findings correlated with cytological findings, but cervical mucus in 3 cases did not coincide. Of the 27 cases 21 were anovular. In all the karyopyknotic index was high. 2 cases showed clinical evidence of inflammation. Of 10 cases of dysmenorrhea, 3 were ovulatory; inflammation was present in 3. In 12 cases of polymenorrhea 7 showed high estrogenic activities. In 1 a polyp had caused the irregular bleeding. The observed shifts of maturation index of cervical cells toward the right are considered indicative of hyperovarian activity. Results show that ovarian activity after sterilization by tubectomy was normal or increased. The increased activity was considered either psychological,neurovascular, or caused by inflammation. Of the 10 cases with inflammation, 9 were associated with menstrual disorders.
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PMID:Menstrual disorders after sterilization with special reference to ovarian activity. 1225 47