Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0745411 (irregular bleeding)
 386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although the progestin-only oral contraceptive (OC) is a safe, effective method for women who cannot use agents that include estrogen because they are breast-feeding or for another reason, it accounts for only 1-26% of the OC market in the US. The progestin-only OC is less effective than combined OCs, and about 5% of women who use rely on the progestin-only formulation and use it correctly will become pregnant in the first year. However, the added contraceptive effect of breast-feeding makes the method nearly 100% effective in lactating women. The progestin-only OC does not interfere with the quality or quantity of breast milk and causes fewer and milder side effects or adverse effects than combined OCs, with irregular bleeding being the most troublesome. The doses of progestin are even lower in the progestin-only OCs than in combined OCs, and the progestin is metabolized within 24 hours, so a back-up method of contraception must be used until the regular schedule has been reinstated for 48 hours if a woman misses a dose by more than 3 hours unless she is fully breast-feeding. The pills are taken daily, and the regimen can be started at any time in the menstrual cycle. Shorter and simpler labeling for the progestin-only OCs was accepted in 1995. The OCs can be given to women immediately postpartum and are a good choice for women who smoke or are over age 35 but should be avoided by women taking hepatic enzyme-inducing medications or by women with a history of gestational diabetes.
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PMID:Maximizing the use of the progestin minipill. 1229 91