Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0745411 (irregular bleeding)
 386 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this editorial, the author discusses the body of evidence linking stilbestrol therapy in pregnant women with the subsequent appearance of vaginal and cervical carcinomas and vaginal adenosis in their daughters. In general, vaginal cancer is quite rare, accounting for only 1 to 2% of all malignant tumors of the female reproductive tract; additionally, most cases in the past have occurred in postmenopausal women. In the early 1970s a series was published of 6 young women diagnosed as having clear cell carcinoma; the diagnoses were established within a short period of time, and the only common factor which was found was that all the patients' mothers had taken stilbestrol during pregnancy. By June 1972, the Registry for Clear Cell Carcinoma of the Genital Tract in Young Women had reports of more than 90 cases; the patients ranged in age from 8 to 25 years old. Although most of the patients presented with irregular bleeding, some were asymptomatic; this points out the necessity of locating all young women who were exposed to stilbestrol during intra-uterine life, and examining them at periodic intervals. The author encourages physicians to be alert to the possibility of these tumors in young women, and points out that stilbestrol was frequently used during pregnancy in Israel in the past.
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PMID:[Editorial: Stilbestrol therapy in pregnant women and adenocarcinoma in their offspring]. 484 3