Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0740577 (acute abdominal pain)
 1,982 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This case report describes an unrecognized adverse effect of an ACE inhibitor (enalapril): attack of acute abdominal pain. This symptom was observed 3 times over a period of 5 years in a 43 year old woman, occurring 24 h after she was taking the ACE inhibitor, and disappearing 3 to 5 days after the withdrawal of enalapril.
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PMID:[Acute abdomen caused by enalapril]. 784 33

Acute abdominal pain is the reason for 5% to 10% of all emergency department visits. In 1 in every 9 patients, operated on for an acute abdomen, laparotomy is negative. In a minority of patients, the acute abdomen is caused by side effects of medication. We present a case of unnecessary abdominal surgery in a patient with acute abdominal pain caused by intestinal angioedema (AE), which was eventually due to angiotensin-converting enzyme inhibitor (ACE-i) use. We hope that this case report increases awareness of this underdiagnosed side effect. Emergency department physicians, surgeons, internists, and family physicians should always consider ACE-i in the differential diagnosis of unexplained abdominal pain. Since early withdrawal of the medication causing intestinal AE can prevent further complications and, in some cases, needless surgery, we propose an altered version of the known diagnostic algorithm, in which ACE-i and nonsteroidal anti-inflammatory drugs-induced AE is excluded at an early stage.
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PMID:Unnecessary surgery for acute abdomen secondary to angiotensin-converting enzyme inhibitor use. 2286 37