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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

61 Boston children aged five years or less with acute diarrhoea were studied for evidence of infection with Escherichia coli strains that produce heat-labile enterotoxin (L.T.) or with a reovirus-like agent associated with childhood gastroenteritis. This represented the first evaluation of the prevalence of disease produced by these two agents in the same population. E. coli, isolated from acute-phase stool specimens, were tested in adrenal-cell tissue-culture and adult-rabbit ileal-loop assays for L.T. Acute and convalescent phase sera, collected from 31 children, were tested by the adrenal-cell assay for anti-L.T. activity. None of the 61 children demonstrated evidence of infection with L.T.-positive E. coli. Paired sera from 31 of the children studied were also tested for evidence of recent infection with the reovirus-like agent by determining titres of immunofluorescent-staining antibody to the serologically related Nebraska calf diarrhoea virus. 11 of the children (35%) had evidence of recent infection. These results suggest that an important proportion of endemic acute diarrhoea of young children in Boston is caused by the reovirus-like agent, and that disease caused by L.T.-producing E. coli is uncommon.
Lancet 1975 Dec 06
PMID:Role of heat-labile toxigenic Escherichia coli and Reovirus-like agent in diarrhoea in Boston children. 5

Diarrheal disease is bacterial in much of the Third World and viral elsewhere. In the poorest underdeveloped country, as many as 15% of children die from diarrheal disease before their third birthday. This association with geographical or climatic areas of the world, however, is actually a reflection of low socioeconomic levels and poor sanitation for practically all of diarrhea's infectious agents are in fact ubiquitous worldwide. Clinical problems associated with acute diarrhea, irrespective of etiology, relate to dehydration that results from abnormal loss of water and electrolytes in stools. Because an infant's total body weight is 70% water (as opposed to 60% in adults), diarrhea is a particular threat. During diarrheal disease, the major event is the disruption of the recycling of electrolyte-rich digestive fluids, which are nomally secreted into the gastrointestinal tract and then 99% reabsorbed. Treatments include preventive methods, such as public health improvements, and rehydration with glucose-water solutions, either orally or intravenously, depending on extent of dehydration. Vaccine development against rotavirus infection has been stymied by inability to cultivate the organism. However, immunoprophylaxis of bacterial diarrheas has made progress in developing vaccines against enterotoxigenic Escherichia coli. The role of immunity transmitted by breastfeeding is also emphasized.
Hosp Pract 1979 Dec
PMID:Acute diarrheal infections in infants. I. Epidemiology, Treatment, and prospects for immunoprophylaxis. 51 Nov 28

The objective of the present investigation is the study and interpretation of the role played by the immunoglobulins, especially IgA, during acute diarrhea in children. IgA, IGG and IgM values in serum and IgA in intestinal secretions were studied in a group of children (between 3 months and 5 years of age) during diarrhea, convalescence and in normals. The method of simple radial immunodiffusion according to Mancini was employed. IgA is the immunoglobulin which suffers the greastest alteration in acute diarrhea. The precipitation halos (the average values), were lower during the diarrhea than in convalescence and in normals.
Acta Gastroenterol Latinoam 1977 Dec
PMID:Immunoglobulin in intestinal secretions. 61 59

Antitoxin titers to heat-labile Escherichia coli enterotoxin were measured in Apache children hospitalized with acute diarrhea and in Apaches of different age groups without diarrhea in Whiteriver, Ariz. The study suggests that in this locale, exposure to enterotocigenic E. coli is probably widespread and occurs early in life. Antitoxin titer rises after idarrheal disease associated with enterotocigenic E. coli infection, however, were not regulary found.
Infect Immun 1975 Dec
PMID:Antibodies to heat-labile Escherichia coli enterotoxin in Apaches in Whiteriver, Arizona. 110 21

To explore the optimal dosing regimen for trimethoprim-sulfamethoxazole (TMP-SMX) when used in combination with loperamide to treat traveler's diarrhea, 190 U.S. adults with acute diarrhea were enrolled in a double-blind, randomized trial in Guadalajara, Mexico. All patients received loperamide (4-mg loading dose; 2 mg after each loose stool, not to exceed 16 mg/day for 3 days) and were randomized to receive a 3-day course of TMP-SMX (160:800 mg twice daily for six doses) (group A), a single large dose of TMP-SMX (320:1,600 mg) (group B), or a large loading dose (320:1,600 mg) followed by standard doses for 3 days (160:800 mg twice daily for five doses) (group C). Patients in group C responded best (P < 0.01), with 75% of subjects recovered from diarrhea in 12 h compared with 34 h (group A) and 33 h (group B). Similar differences in favor of group C were noted in the subset of patients who presented with moderate to severe diarrhea. On average, patients in group C took significantly (P < 0.05) less loperamide (1.2 mg) after the 4-mg loading dose compared with patients in group A (2.4 mg) or group B (2.0 mg). We conclude that the most efficacious treatment of traveler's diarrhea in the interior of Mexico is to take loperamide in usual doses to control symptoms in combination with a single large dose of TMP-SMX, which should then be continued for 3 days in standard doses.
Antimicrob Agents Chemother 1992 Dec
PMID:Optimal dosing of trimethoprim-sulfamethoxazole when used with loperamide to treat traveler's diarrhea. 148 52

Data regarding factors contributing to acute diarrhoea in children under five years in urban populations in Sri Lanka is meagre. Studies of diarrhoeal disease have been limited mainly to descriptive epidemiological investigations. A case control study on 200 families in the Galle Municipality was undertaken to identify some of the social, behavioural and environmental factors contributing to childhood diarrhoea. Twelve variables were studied by logistic regression, and the following variables were identified as conferring a significant risk of causing diarrhoeal disease in children below five years in an urban setting in Sri Lanka; (1) unavailability of pipe-borne water in the house (2) lack of water-seal latrine in the household (3) low level of mother's education and her lack of awareness regarding infectious nature and mode of spread of diarrhoea (4) not disposing of children's faeces in a latrine (5) improper disposal of garbage.
Ceylon Med J 1992 Dec
PMID:Risk factors contributing to acute diarrhoeal disease in children below five years. 148 45

Controversy continues regarding the optimal composition of glucose electrolyte oral rehydration solutions for the treatment of acute diarrhoea. Four perfusion models (normal human jejunum, normal rat small intestine, cholera toxin treated secreting rat small intestine and rotavirus infected rat small intestine) have been developed and used to compare the efficacy of a hypotonic oral rehydration solution with standard United Kingdom British National formulary and developing world oral rehydration solutions (WHO). Despite obvious physiological and pathophysiological differences between these models there was general congruence in the water and solute absorption profiles of the different oral rehydration solutions. Hypotonic oral rehydration solution promoted significantly greater water absorption than other oral rehydration solutions in all rat models (p < 0.001) but apparently increased water absorption failed to achieve significance in human jejunum. British National Formulary-oral rehydration solution was unable to reverse net water secretion in both rotavirus and cholera toxin models. Net sodium absorption from hypotonic and WHO-oral rehydration solutions was significantly greater than from the low sodium British National Formulary-oral rehydration solutions (p < 0.001) except in the rotavirus model when absorption was similar to hypotonic-oral rehydration solutions. These findings show that there is agreement in the apparent efficacy of oral rehydration solutions in these animal and human perfusion models, and that improved water absorption with adequate sodium absorption may be achieved by reducing oral rehydration solution osmolality.
Gut 1992 Dec
PMID:Water and solute absorption from a new hypotonic oral rehydration solution: evaluation in human and animal perfusion models. 148 67

Collagenous colitis is a newly recognized entity presenting clinically as chronic watery diarrhea and histologically by a thickened subepithelial collagenous band in colonic biopsies. We report the case of a middle aged woman affected of acute diarrhea in whom, after ruling out its main etiologies, the diagnosis of collagenous colitis was made.
Rev Esp Enferm Dig 1992 Dec
PMID:[Collagenous colitis as a cause of acute diarrhea]. 149 63

We present the results of a 187 cases acute diarrhea study managed in the Short Stay Unit of Clinic Universitary Hospital of Zaragoza during 1987-1988. To that aim, we designed an actuation protocol which included the gathering of several data, the realization of complementary studies and the evolutive pursuit. The coproculture resulted positive in a 54.5% of cases and Salmonella was the microorganism more frequently isolated. Most of the species were sensible to common antibiotics and all of them sensible to norfloxacin. Nearly a third part of patients developed some kind of complication. Therefore we infer that acute diarrhea may be subsidiary of diagnosis and treatment in Short Stay Units.
An Med Interna 1991 Dec
PMID:[Expediency of hospital admission for acute diarrhea syndrome in a short-stay unit]. 178 13

To identify the prognostic indicators and risk factors for increased duration of acute diarrhoea and for occurrence of persistent diarrhoea (i.e. acute episodes lasting longer than 14 days) in children under three years, a systematic sample (3690) of patients attending a large treatment centre in Bangladesh was analysed using multiple regression, logistic regression and stratified (Mantel-Haenszel) analysis. Significant prognostic indicators or risk factors for increase in duration of acute diarrhoea, after adjusting for confounders, include bloody or mucoid diarrhoea, concomitant signs of chest infection, presence of vitamin A deficiency signs, decreased weight for age, routine use of contaminated surface water, lack of breastfeeding and increasing age; presence of rotavirus or enterotoxigenic Escherichia coli or Vibrio cholerae 01 in stool had negative association. In logistic regression and stratified analysis these factors, except for lack of breastfeeding and age, were also found to be risk factors or prognostic indicators of persistent diarrhoea. Policy implications of these findings for programmes to reduce morbidity and mortality from persistent diarrhoea include development of effective vaccines against dysentery-causing Shigella, programmes to prevent vitamin A deficiency, protein energy malnutrition and acute respiratory infections in children, and long-term programmes to provide clean water for all day-to-day needs.
Int J Epidemiol 1991 Dec
PMID:Prognostic indicators and risk factors for increased duration of acute diarrhoea and for persistent diarrhoea in children. 180 Apr 5


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