Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute infections of childhood are associated with an increased of xerophthalmia, apparently due to depletion of vitamin A stores. The mechanism responsible for this is not known. Recently, it has been reported that severe infections in adult patients (ie, sepsis and pneumonia) result in excretion of large quantities of retinol in the urine. In 44 children hospitalized for treatment of acute diarrhea we found mean urinary excretions of 1.44 mumol retinol/24 h on day 1 of hospitalization, 0.62 mumol retinol/24 h on day 2, and 0.23 mumol/24 h on day 3. Healthy control subjects matched for age did not excrete measurable amounts of retinol in the urine. Retinol excretion was associated strongly with rotavirus diarrhea and presence of fever. Furthermore, serum retinol concentration was negatively associated with duration of diarrhea before hospitalization, suggesting that urinary excretion of retinol may be an important contributor to vitamin A depletion.
 ...
PMID:Urinary excretion of retinol in children with acute diarrhea. 776 30

Vitamin A administration in children reduces the incidence of severe diarrhea during the subsequent few months. We therefore examined the effect of treatment with vitamin A during acute diarrhea on the episode duration and severity. In a double-blind controlled field trial, 900 children 1 to 5 y of age with acute diarrhea of < or = 7 d duration were randomly assigned to receive vitamin A (60 mg) or a placebo. Children were followed up at home every alternate day until they recovered from the diarrheal episode. In all study children, those treated with vitamin A had a significantly lower risk of persistent diarrhea [odds ratio (OR) 0.30, 95% confidence interval (CI) 0.07-0.97], but there was no effect on the mean diarrheal duration or the mean stool frequency, in the subgroup of children who were not breast-fed, the mean diarrheal duration [ratio of geometric means (GM) 0.84, 95% CI 0.72-0.97], mean number of stools passed after the intervention (ratio of GM 0.73, 95% CI 0.56-0.95), the proportion of episodes lasting > or = 14 d (P = 0.002) and the percentage of children who passed watery stools on any study day (OR 0.40, 95% CI 0.21-0.77) were significantly lower in those treated with vitamin A. We conclude that administration of vitamin A during acute diarrhea may reduce the severity of the episode and the risk of persistent diarrhea in non-breast-fed children. Similar benefit was not seen in breast-fed children.
 ...
PMID:Breast-feeding status alters the effect of vitamin A treatment during acute diarrhea in children. 904 May 45

The objective of this study was to measure in children with acute diarrhea the apparent absorption and retention of the macronutrients and some micronutrient present in a formula prepared with chicken and a formula prepared with soybean protein. Fourteen male children (9 months old) with acute diarrhea were assigned to each of these formulas and the consumption and excretion of the studied nutrients were monitored during 48 h. The results showed that the children assigned to the chicken formula consumed more protein and less fat than those in the soybean protein formula. These differences however were associated with differences in the composition of the formulas offered rather than to differences in protein or fat utilization. Fecal mass (800 g/48 h) was similar in both groups and the macronutrient content of the feces, reflected well the amount consumed. The apparent absorption of fat (63%), nitrogen (75%) and carbohydrates (78%) resulted similar in both groups and there were no differences in the retention of nitrogen which approximated 55%. The digestible energy and the metabolizable energy of both formulas, also resulted equal. In general the children excreted more urinary ammonia and less creatinine than healthy children but there were no differences in the excretion of these metabolites between the children assigned to the chicken or to the soybean protein formulas. The retention of Zn (47%) and Ca (72%) were also similar in both groups and they excreted a high (0.17 mg/48 hr) but similar amount of Vitamin A. In summary, these results showed that from a nutritional point of view, the chicken and the soybean protein formulas were equally utilized during the acute phase of diarrhea.
 ...
PMID:[Nutrient utilization in children with acute diarrhea fed with formulas containing chicken and soybean]. 1048 91

Vitamin A status was measured in 50 pre-school children with acute and persistent diarrhoea. It was measured by (a) Fluorometric micromethod and (b) Conjunctival impression cytology (CIC). The results were compared with 25 normal children. Vitamin A status was lower in children with persistent diarrhoea whereas the results were comparable between the children with acute diarrhoea and control subjects.
 ...
PMID:Vitamin a status in children with diarrhoea. 2310 39