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Target Concepts:
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Query: UMLS:C0740441 (
acute diarrhea
)
2,275
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Atopic dermatitis (AD) and food allergy are closely linked; however, the mechanisms that guide the progression of AD to allergic inflammatory responses at other mucosal surfaces, including the gastrointestinal tract, are not well understood. Here, we determined that exposure of mice that have been epicutaneously sensitized with
thymic stromal lymphopoietin
(
TSLP
) and antigen to repeated oral doses of the same antigen induced
acute diarrhea
and anaphylaxis. In this model, loss of
TSLP
signaling specifically in DCs led to loss of induced allergic diarrhea through lack of sensitization. While
TSLP
responses were not required during oral allergen challenge, CD4(+) T cells were required and transferred disease when introduced into naive hosts. In addition, oral exposure to the antigen prior to skin sensitization blocked development of allergic disease. Finally, mice lacking the receptor for IL-25 failed to develop
acute diarrhea
and anaphylaxis, highlighting a role for IL-25 in the initiation of type 2 immunity in the intestine. These results demonstrate a role for
TSLP
and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions.
...
PMID:Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. 2536 22
