Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activity of lysozyme in feces was estimated in a control group of 50 healthy infants and in a group of 152 infants with acute diarrhoea. All infants investigated were artificially nourished. In the latter group the activity of lysozyme was estimated twice: a) at the beginning of clinically active phase of the disease and (b) in the convalescence period immediately after withdrawal of clinical symptoms. The range of normal values was 14.9--77.0 (average 44.0) of egg-white lysozyme units/g dry feces. In acute diarrhoea the activity of lysozyme in feces was found to be elevated in 72.4% of cases in the first determinations and in an additional 7.6% of cases in the second determination (i.e. a total of 80% of cases in both determinations). The average elevations of lysozyme activity in the feces and the dynamics of their normalization after withdrawal of clinical symptoms were generally related to the severity of the disease.
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PMID:Diagnostic value of lysozyme activity estimation in the feces of infants with acute diarrhoea. 67 Sep

Defining etiology of acute diarrhea is critical to disease therapy and prevention. In this review we look at recent developments in etiologic agents of acute diarrhea and advances in therapy and prevention of the illness. Newly appreciated agents include enterotoxigenic Bacteroides fragilis, Klebsiella oxytoca and Laribacter hongkongensis. Atypical enteropathogenic E. coli (EPEC) strains lacking the gene for epithelial attachment appear to be more important as causes of diarrhea than traditional EPEC strains. Enterotoxigenic E. coli and enteroaggregative E. coli diarrhea known to be important abroad, have recently been shown to occur in the United States. Non-O157:H7 strains of Shiga toxin-producing E. coli are increasing and infrequently are being sought. There is currently a serious epidemic of nosocomial diarrhea due to a fluoroquinolone-resistant and more virulent and difficult to treat strain of C. difficile. Rotavirus vaccine development should lead to reduction of infant gastroenteritis mortality in infants living in developing regions. Noroviruses produce outbreaks of water- and food-borne disease but show broad genetic diversity. Reduced osmolarity oral rehydration treatment (ORT) and recombinant human lactoferrin/lysozyme plus rice-based ORT effectively treat acute diarrhea. Probiotics were shown to be effective in preventing antibiotic associated- and C. difficile-diarrhea. Rifaximin prevents and azithromycin effectively treats travelers' diarrhea.
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PMID:Advances in defining etiology and new therapeutic approaches in acute diarrhea. 1782 22