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Query: UMLS:C0740441 (acute diarrhea)
 2,275 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The microflora and pH of gastric contents were determined in breast-fed and in bottle-fed normal infants, in well nourished infants with acute diarrhoea and in infants with chronic diarrhoea and protein-calorie malnutrition. The last group of infants was reevaluated after recovery from diarrhoea and protein-calorie malnutrition. A bactericidal pH effect below 2-5 was observed. Bottle-fed controls had low pH values and low bacterial concentrations, whereas infants with chronic diarrhoea and protein-calorie malnutrition had high pH values and bacterial overgrowth, essentially of Gram-negative bacilli. After recovery, the only remaining alteration was the frequent isolation of yeast-like fungi in low concentrations. Infants with acute diarrhoea, except for the isolation more frequently of yeast-like fungi, presented no alterations; this seems to indicate that pH alterations and Gram-negative bacilli overgrowth occurred during the evolution of the disease to a chronic state. Breast-fed normal infants had hydrogen-ion concentrations similar to those of the chronic diarrhoea group, but without Gram-negative bacilli overgrowth, suggesting that other factors, besides pH, regulate bacterial growth in the gastric contents of these groups of infants.
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PMID:Gastric pH and microflora of normal and diarrhoeic infants. 0 Feb 74

Much clinical experience has been gained in the use of the glucose/electrolyte oral solutions in the treatment of acute diarrhea. Those patients who are in shock or too weak to drink need intravenous fluids to correct their total deficit. With isotonic polyelectrolyte fluids rehydration may be achieved in 2-4 hours. Subsequently, most of these patients can be given oral fluids to replace continuing stool loss. Patients who are not in shock and who are sufficiently strong to drink at the outset nearly always can be rehydrated with oral fluids alone. Vomiting is most likely caused by acidosis and volume depletion, and these can be corrected in severely dehydrated patients by intravenous therapy and by oral therapy in those not in shock and able to drink by oral therapy. Proponents of oral glucose/electrolyte therapy for diarrhea, like other proponents of new treatments, have great visions of its benefits to the world, yet these visions require validation. The biggest problem will be getting glucose and electrolytes to where they are most needed -- at the level of home and village.
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PMID:Editorial: Oral glucose/electrolyte therapy for acute diarrhoea. 4 28

61 Boston children aged five years or less with acute diarrhoea were studied for evidence of infection with Escherichia coli strains that produce heat-labile enterotoxin (L.T.) or with a reovirus-like agent associated with childhood gastroenteritis. This represented the first evaluation of the prevalence of disease produced by these two agents in the same population. E. coli, isolated from acute-phase stool specimens, were tested in adrenal-cell tissue-culture and adult-rabbit ileal-loop assays for L.T. Acute and convalescent phase sera, collected from 31 children, were tested by the adrenal-cell assay for anti-L.T. activity. None of the 61 children demonstrated evidence of infection with L.T.-positive E. coli. Paired sera from 31 of the children studied were also tested for evidence of recent infection with the reovirus-like agent by determining titres of immunofluorescent-staining antibody to the serologically related Nebraska calf diarrhoea virus. 11 of the children (35%) had evidence of recent infection. These results suggest that an important proportion of endemic acute diarrhoea of young children in Boston is caused by the reovirus-like agent, and that disease caused by L.T.-producing E. coli is uncommon.
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PMID:Role of heat-labile toxigenic Escherichia coli and Reovirus-like agent in diarrhoea in Boston children. 5

20 consecutive child admissions to a Calcutta, India, hospital with acute diarrhea and moderate to severe clinical dehydration were studied. They were treated with an oral sucrose/electrolyte solution, which achieved complete hydration in 19 out of the 20 cases; 1 child did not respond and needed intravenous therapy. Vomiting, abdominal distension, and appearance of sugar in the stools during oral therapy did not interfer with its success. A child was considered to have recovered when the body weight had stabilized and when there was no further diarrhea, a process requiring 5-6 days. In addition, recovery involved restoration of plasma-bicarbonate to normal levels, falls in the hematocrit values and in the plasma specific gravidity, and complete clinical recovery. Solutions of glucose/electrolytes have already been used in the treatment of acute diarrhea. Replacement of glucose with sucrose is preferable since it is less expensive and more readily available in developing areas. This study showed that replacement of the glucose with sucrose is as effective.
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PMID:Evaluation of a sucrose/electrolyte solution for oral rehydration in acute infantile diarrhoea. 6 56

The enterotoxigenicity of strains of Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli, which represented the predominant coliform species isolated from the jejunum of 12 patients with tropical sprue and 5 with the blind-loop syndrome, was quantitatively assessed in terms of the ability of toxin preparations to induce water secretion as assayed by in-vivo perfusion in the rat jejunum. All 12 patients with sprue harboured 1 or more highly toxigenic strains--14 of the 16 strains isolated from this group produced heat-labile and/or heat-stable toxins which were as potent as toxins derived from strains isolated from persons with acute diarrhoea and documented as toxigenic. None of the 9 strains isolated from patients with the blind-loop syndrome produced potent toxins. This difference between the coliform bacteria in sprue and the blind-loop syndrome probably accounts, at least partly, for the different intestinal response in these two disorders to contamination by these organisms.
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PMID:Enterotoxigenicity of colonising coliform bacteria in tropical sprue and blind-loop syndrome. 7 10

Gastrointestinal physiology, and the pathophysiology, diagnosis, symptoms and treatment of acute and chronic diarrhea are reviewed. Drugs used in the treatment of diarrhea include opiates (morphine, codeine), synthetic anti-diarrheals (diphenoxylate, loperamide), anticholinergics (atropine, propantheline), adsorbents (kaolin, pectin, cholestyramine resin) and Lactobacillus acidophilus. Chronic diarrhea and acute diarrhea caused by microorgansims, drugs and viruses are described. The management of diarrhea can be divided into three categories: (1) supportive therapy (fluid and electrolyte replacement); (2) symptomatic therapy which improves the consistency of the stool and reduces the frequency of bowel movements; and (3) specific therapy aimed at treating the cause (e.g., antibiotics for bacteria-induced diarrhea) or blocking the cellular mechanisms of fluid and electrolyte loss. Most acute diarrheal conditions can be managed successfully by avoiding oral solids and ingesting carbohydrate-electrolyte solutions. Synthetic antidiarrheals may increase the toxicity associated with bacterial diahhrea.
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PMID:Drug therapy reviews: pharmacotherapy of diarrhea. 11 47

Since in the past, Aeromonas hydrophila had been isolated from all cases of human infection described. A. punctata and the anaerogenic sub-species were considered as apathogenic. From the case described, a close association between acute diarrhea with vomiting and the identification of A. punctata subsp. caviae becomes evident so that a conditional pathogenicity of this sub-species must be assumed. The question is discussed whether a preceding disturbance of the intestinal habitat in the presence of a particular susceptibility of the gastrointestinal tract promoted gastro-enteritis. Infection may have been brought about by the ingestion of surface water contaminated by sewage. Attention is again drawn to the fact that in the case of enteritis occuring during the open-air bathing season, faeces samples should also be examined for their Aeromonas content which may be performed by a simple indophenol or so-called cytochrome oxidase reaction of the aerobic flora in feces by rubbing off colonies into a corresponding test strip.
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PMID:[Aeromonas punctata subsp. caviae as the causative agent of acute gastroenteritis (author's transl)]. 17 15

Rotaviruses (duoviruses) can be found in more than half the cases of acute diarrhoea in children up to the age of six or seven. About that age almost everyone has antibodies to them. Second infections occur and may not be as rare as laboratory findings so far suggest. Very young infants sometimes get subclinical disease-the effect of maternal antibody transmitted across the placenta? Very similar viruses, all possessing a common antigen detectable by immunofluorescence, are known to infect and/or cause diarrhoea in children, calves, piglets, mice, foals and monkeys. The calf virus and the human virus both infect piglets; piglet virus infects calves; we don't know whether any of these can infect children. Other mammals probably have similar diarrhoea viruses. An antigen common to all these viruses is probably in the inner capsid layer, and "species-specific" antigens are probably in the outer capsid layer. A precise test for comparing different strains is bably needed. Adenoviruses possibly cause a smaller proportion of cases of diarrhoea. Coronaviruses, well-known as enteric pathogens of pigs and calves, appear also to infect adults and children. 27 nm particles and 22-23 nm particles of density 1.4 (and other particles) can be found in faeces of children with natural diarrhoea and adults with experimental diarrhoea, sometimes in enormous numbers. It is not yet established whether they cause disease. Rotaviruses, animal coronaviruses and "Norwalk" virus attack the disaccharidase-producing epithelium of the small bowel; adenovirus pathology is unknown.A safe attenuated live vaccine strain of the human rotavirus urgently needs to be developed.
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PMID:Implications of recent virological researches. 18 37

The rate of poliovirus excretion was found to be 64.6% in a group of 108 normal children and 11.95% in 184 diarrheal children. Diarrhea was due to Shigella in 70% of cases. This drew our attention to the presence of an etiologic relationship between the two findings, which may have a direct effect on the low efficiency of oral poliovaccine in our Country. Effect of Shigella infection on the take of oral poliovaccine was investigated in 14 normal and 10 children having acute diarrhea due to Shigella. Vaccine virus excretion was detected in 64.2% of normal children and only in 10% of diarrheal children. In vitro studies were done to determine the effect of killed Shigella suspensions or their endotoxin on the replication of poliovirus in tissue culture. Reduction of virus titre from 1-3 logs in the presence of killed Shigella or its endotoxin was observed. The sites of action and interfering factor (s) are discussed.
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PMID:The influence of bacillary dysentery on the efficiency of oral poliovaccine in Egypt. 19 25

Rotavirus and its antibody were detected by paper disk solid-phase radioimmunoassay or electron microscopy in feces of infants and young children with acute diarrhea. The fecal specimens in which rotavirus was detectable often contained a high titer of antibodies, which were shown by radioimmunoassay to belong mainly to the immunoglobulin G class. Rotavirus was rarely detected in the specimens containing immunoglobulin A antibodies. By dissociation tests carried out by radioimmunoassay, it was shown that the rotavirus particles in some specimens had the same antibody-binding capacity as did cultured simian rotavirus (SA-11), but antibodies in feces usually had low avidity, probably resulting from enzymatic digestion.
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PMID:Human rotavirus and its antibody: their coexistence in feces of infants. 20 17


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